Postdoctoral Research Assistant

Division: Blizard Institute
Wage: £40,223 – £47,178
Reference: 1524
Location: Whitechapel
Date posted: 12 March 2024
Time limit: 9 April 2024

Additional particulars and apply

Overview

Concerning the Position
This full-time PDRA publish would significantly swimsuit an formidable early profession researcher with an curiosity in discovering endogenous RNAs and peptides that mediate anti-tumour immunity and the chromatin-associated proteins that regulate them, together with the human silencing hub. The publish is targeted on non-small cell lung most cancers. The candidate would work in a dynamic and numerous group at Queen Mary College (QMUL) and with exterior co-investigators and collaborators and this work would inform future most cancers therapies and vaccines. The function might characterize a stepping stone for somebody keen on establishing their very own lab afterwards or creating their expertise, community and alternatives and there are prospects for versatile or part-time working.

About You
The profitable candidate will lead their very own challenge targeted on chromatin mechanisms of regulation of tumour immunogenicity, with a concentrate on the human silencing hub and on non-small cell lung most cancers. Discovery research will probably be based mostly in lung most cancers cells strains with KRAS activating mutations initially and can concentrate on chromatin mechanisms, nucleic acid sensing and darkish antigen discovery. Findings will probably be validated utilizing FluoroSpot and move cytometry panels on peripheral blood mononuclear cell samples from adenocarcinoma and lung squamous cell carcinoma sufferers. A tumour transplantation mannequin in mice will probably be used to evaluate how knockout or inhibition of chromatin regulators impacts on anti-tumour immunity in vivo. The postholder will run some bioinformatics analyses of their very own information (RNAseq, CUT&RUN information). All goals will probably be supported by exterior co-investigators and collaborators.

Concerning the Institute

The Blizard Institute was established in 2003 and is one in every of six Institutes inside the College of Drugs and Dentistry, QMUL. The Institute includes roughly 350 workers based mostly in 4 tutorial Centres and one Public Engagement Centre and helps a mixed whole of c750 postgraduate analysis and taught college students. The Institute goals to ship excellence in all features of analysis, educating and medical service.

About Queen Mary
At Queen Mary College of London, we consider {that a} range of concepts helps us obtain the beforehand unthinkable.

All through our historical past, we’ve fostered social justice and improved lives via tutorial excellence. And we proceed to stay and breathe this spirit as we speak, not as a result of it’s merely ‘the fitting factor to do’ however for what it helps us obtain and the mental brilliance it delivers.

We proceed to embrace range of thought and opinion in the whole lot we do, within the perception that when views collide, disciplines work together, and views intersect, really unique thought takes type.

Advantages
We provide aggressive salaries, entry to a beneficiant pension scheme, 30 days’ depart every year (pro-rata for part-time/fixed-term), a season ticket mortgage scheme and entry to a complete vary of non-public {and professional} growth alternatives. As well as, we provide a variety of labor life stability and household pleasant, inclusive employment insurance policies, versatile working preparations, and campus amenities together with an on-site nursery on the Mile Finish campus.

Queen Mary’s dedication to our numerous and inclusive group is embedded in our appointments processes. Cheap changes will probably be made at every stage of the recruitment course of for any candidate with a incapacity. We’re open to contemplating functions from candidates wishing to work flexibly.

Additional particulars and apply