Postdoctoral Research Associate

Job id: 086705. Wage: £43,205 – £46,732 every year, together with London Weighting Allowance.

Posted: 22 March 2024. Deadline: 02 April 2024.

Enterprise unit: College of Life Sciences & Drugs. Division: Complete Most cancers Centre.

Contact particulars:Dr Gilbert Fruhwirth and Dr Rachel Evans. [email protected]; [email protected]

Location: Man’s Campus. Class: Analysis.

Job description

Context

This place is a part of a prestigious Most cancers Analysis UK Early Detection and Prognosis Award to King’s School London. The intention of the challenge is to guage an oncogenic receptor tyrosine kinase, which is upregulated in aggressive malignancies equivalent to non-small cell lung most cancers (NSCLC), as a potential biomarker for early NSCLC detection and monitoring. This will likely be achieved by implementing parallel tracks of technical, organic, and medical validation following the biomarker/imaging biomarker roadmap technique. This place is particularly devoted to the event of this early detection biomarker toolbox for each blood-borne biomarker evaluation and non-invasive whole-body PET imaging. 

Position

The profitable candidate could have a powerful curiosity in most cancers biomarker analysis and will likely be a part of a multi-disciplinary crew of most cancers researchers, cell biologists, and imaging scientists. The put up holder will likely be designing and performing a wide range of in vitro, in vivo, and ex vivo experiments in shut collaboration with different crew members. Importantly, it’s a requirement of this challenge to collaborate with current groups of scientists with numerous backgrounds inside and outdoors the division, particularly with colleagues offering specialist tumour fashions, antibody builders, and animal technicians. The put up holder could have entry to cutting-edge applied sciences together with antibody validation platforms, patient-derived tumour fashions, and quantitative whole-body tumour and ImmunoPET imaging alongside entry to a wide range of state-of-the-art King’s amenities equivalent to these for stream cytometry, superior microscopy, and preclinical tumour fashions. The function includes work at completely different CR-UK Metropolis-of-London Centre Campuses as required by experimental necessities. 

This put up will likely be provided on a fixed-term contract for 34 months initially, with additional extension of one other 2 months.

It is a full-time put up – 100% full time equal.

Key duties

• To carry out in vitro, in vivo, and ex vivo experimentation required to validate blood-borne and imaging-based most cancers biomarkers.
• To carry out in vivo and ex vivo experimentation with patient-derived and animal tumour fashions.
• To work with macroscopic in vivo imaging applied sciences together with PET imaging.
• To work with varied microscopic brightfield and fluorescence imaging applied sciences.
• To work with immunological strategies together with however not restricted to multi-parameter stream cytometry and immunoblotting.
• To work independently on an outlined challenge and to seek the advice of when acceptable.
• To design, implement, and handle new and current challenge elements.
• To collaborate and assist scientific collaboration in line with the put up within the curiosity of the challenge crew.
• To be totally accustomed to related scientific literature.
• To take accountability for repeatedly setting up manuscripts/reviews or elements thereof in glorious written English for publication in excessive impression journals.
• To take part and current work repeatedly in crew conferences and conferences.
• To take care of correct, up-to-date data of labor and its findings.
• To work at varied CRUK CoL websites as required for optimum challenge progress.
• To oversee and prepare college students and junior employees.
• Every other needed duties in line with the character and grade of the put up, together with participation in shared roles of laboratory administration and sustaining a secure laboratory setting.

Abilities, data, and expertise

Important standards

PhD in Most cancers Biology, Most cancers Immunology, Molecular Imaging, or related associated subject. Candidates who’ve submitted their PhD thesis and their PhD viva confirmed to happen previous to put up graduation are additionally eligible.

Expertise in antibody dealing with and validation.

Expertise in commonplace cell and molecular biology strategies.

Expertise in mammalian cell tradition.

Expertise in most cancers/tumour biology.

Competent in design and performing in vivo animal tumour fashions.

Information of related NSCLC tumour fashions.

Expertise in multiparameter stream cytometry

Proof of laborious working and abilities to prioritize work.

Competent in following and adapting protocols.

Wonderful communication abilities, together with evaluation and presentation of information.

Holder of an lively UK Residence Workplace Private License (PIL) or equal.

Fascinating standards

Expertise in Most cancers Biomarker Analysis.

Expertise in exosome isolation from peripheral blood.

Expertise in immunohistochemistry and fluorescence microscopy (pattern preparation and downstream evaluation).

Expertise in preclinical molecular radionuclide imaging.

Related publication observe report.

Interviews are anticipated to be held on Thursday twenty fifth April 2024 with candidates being knowledgeable round two weeks earlier than the scheduled interview.

This put up is topic to Occupational Well being clearance.