KINGS COLLEGE LONDON

23 Mar 2024
Job Data

Organisation/Firm: KINGS COLLEGE LONDON
Analysis Area: Literature
Chemistry
Researcher Profile: Recognised Researcher (R2)
Established Researcher (R3)
Nation: United Kingdom
Utility Deadline: 2 Apr 2024 – 00:00 (UTC)
Kind of Contract: Different
Job Standing: Full-time
Is the job funded by means of the EU Analysis Framework Programme?: Not funded by an EU programme
Is the Job associated to employees place inside a Analysis Infrastructure?: No

Provide Description

Job description

Context

This place is a part of a prestigious Most cancers Analysis UK Early Detection and Prognosis Award to King’s School London. The purpose of the undertaking is to judge an oncogenic receptor tyrosine kinase, which is upregulated in aggressive malignancies comparable to non-small cell lung most cancers (NSCLC), as a potential biomarker for early NSCLC detection and monitoring. This might be achieved by implementing parallel tracks of technical, organic, and scientific validation following the biomarker/imaging biomarker roadmap technique. This place is particularly devoted to the event of this early detection biomarker toolbox for each blood-borne biomarker evaluation and non-invasive whole-body PET imaging.

Position

The profitable candidate could have a powerful curiosity in most cancers biomarker analysis and might be a part of a multi-disciplinary crew of most cancers researchers, cell biologists, and imaging scientists. The publish holder might be designing and performing a wide range of in vitro, in vivo, and ex vivo experiments in shut collaboration with different crew members. Importantly, it’s a requirement of this undertaking to collaborate with current groups of scientists with numerous backgrounds inside and out of doors the division, specifically with colleagues offering specialist tumour fashions, antibody builders, and animal technicians. The publish holder could have entry to cutting-edge applied sciences together with antibody validation platforms, patient-derived tumour fashions, and quantitative whole-body tumour and ImmunoPET imaging alongside entry to a wide range of state-of-the-art King’s services comparable to these for movement cytometry, superior microscopy, and preclinical tumour fashions. The function entails work at completely different CR-UK Metropolis-of-London Centre Campuses as required by experimental necessities.

This publish might be supplied on a fixed-term contract for 34 months initially, with additional extension of one other 2 months.

This can be a full-time publish – 100% full time equal.

Key tasks

To carry out in vitro, in vivo, and ex vivo experimentation required to validate blood-borne and imaging-based most cancers biomarkers.
To carry out in vivo and ex vivo experimentation with patient-derived and animal tumour fashions.
To work with macroscopic in vivo imaging applied sciences together with PET imaging.
To work with numerous microscopic brightfield and fluorescence imaging applied sciences.
To work with immunological strategies together with however not restricted to multi-parameter movement cytometry and immunoblotting.
To work independently on an outlined undertaking and to seek the advice of when applicable.
To design, implement, and handle new and current undertaking elements.
To collaborate and assist scientific collaboration in line with the publish within the curiosity of the undertaking crew.
To be totally accustomed to related scientific literature.
To take accountability for often developing manuscripts/studies or elements thereof in glorious written English for publication in excessive influence journals.
To take part and current work often in crew conferences and conferences.
To keep up correct, up-to-date data of labor and its findings.
To work at numerous CRUK CoL websites as required for optimum undertaking progress.
To oversee and prepare college students and junior employees.
Another mandatory duties in line with the character and grade of the publish, together with participation in shared roles of laboratory administration and sustaining a secure laboratory atmosphere.

Expertise, information, and expertise

Important standards

PhD in Most cancers Biology, Most cancers Immunology, Molecular Imaging, or related associated area. Candidates who’ve submitted their PhD thesis and their PhD viva confirmed to happen previous to publish graduation are additionally eligible.

Expertise in antibody dealing with and validation.

Expertise in commonplace cell and molecular biology methods.

Expertise in mammalian cell tradition.

Expertise in most cancers/tumour biology.

Competent in design and performing in vivo animal tumour fashions.

Data of related NSCLC tumour fashions.

Expertise in multiparameter movement cytometry

Proof of exhausting working and abilities to prioritize work.

Competent in following and adapting protocols.

Wonderful communication abilities, together with evaluation and presentation of knowledge.

Holder of an energetic UK Dwelling Workplace Private License (PIL) or equal.

Fascinating standards

Expertise in Most cancers Biomarker Analysis.

Expertise in exosome isolation from peripheral blood.

Expertise in immunohistochemistry and fluorescence microscopy (pattern preparation and downstream evaluation).

Expertise in preclinical molecular radionuclide imaging.

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