Postdoctoral Research Associate

Job title:

Postdoctoral Research Associate

Company

University of Edinburgh

Job description

Job Description:UE07 £40,247 to £47,874Institute of Cell Biology, School of Biological SciencesCollege of Science and EngineeringFull-time (35 hours per week)Fixed Term (12 months)Start date 1st May 2025The Opportunity:Applications are invited for Postdoctoral Research Associate post in the laboratory of Prof. Julie Welburn, funded by BBSRC for 12 months, up to 24 months. The laboratory investigates fundamental mechanisms of the microtubule cytoskeleton in cell organization in different cell types, and in cell division and disease at the molecular and cellular level. In human cells, there are multiple a-tubulin isotypes and b-tubulin isotypes distributed in different cell types. Many pathogenic tubulin mutations are dominant negative and associated with tubulinopathies and cancer, yet the pathogenic mechanism is unclear.The project will involve using cell biology and biochemical and structural approaches to 1) understand how the isotype-composition and properties of microtubule tracks control motor-cargo complexes and cellular architecture to modulate cell function and properties 2) discover the mechanism underlying pathogenic tubulin mutations.We are now looking for an enthusiastic and talented researcher to join our team investigating the molecular diversity and function of tubulin isotypes and the mechanisms that underlie tubulin-isotype-specific diseases. You will play a major role in the design and conduct of the research project and be trained in the relevant techniques. You should have, or will shortly obtain, a PhD in a relevant subject area and will have experience in structural biology and biochemistry or/and advanced imaging and image analysis. Training can also be offered. An outstanding academic track record is essential and at least one first author publication in a prominent journal is expected.Your skills and attributes for success:

• Must hold (or close to complete) a PhD in biochemistry, structural biology, or related discipline
• Work independently and have experience in general lab techniques including protein purification, cloning, cell culture and imaging
• It would be desirable to have experience in structure determination although training can be provided

Click to view a copy of the full (opens new browser tab)As a valued member of our team, you can expect:

• A competitive salary of £40,247 to £47,874
• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community.
• Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our

(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits.Championing equality, diversity and incusion:The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab).The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.Key dates to noteThe closing date for applications is 19 November 2024.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.Interview dates TBC.About Us: As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:The Institute of Cell Biology (ICB) is a world-leading research centre for cell and molecular biology. Our research aims to uncover fundamental mechanisms responsible for the stability, transmission and expression of genetic information in both prokaryotes and eukaryotes, as well as studies of processes underlying microbial physiology and pathogenesis. We work with a wide range of experimental systems including cell culture, bacteria, yeast, Drosophila and mouse.We work closely with other areas of the School and with colleagues in the College of Medicine and Veterinary Medicine, and have particularly strong links with members of the Institute of Structural and Molecular Biology and with SynthSys (the centre for Synthetic & Systems Biology) with whom we have common research interests and many collaborative projects. Facilities include high through-put DNA sequencing, protein production and purification, biophysical and kinetic analysis of proteins, in silico screening for drug leads, proteomics, optical and electron microscopy.ICB incorporates the Wellcome Trust Centre for Cell Biology, a flagship research centre answering fundamental questions relating to cellular function. Our research is funded by, amongst others, BBSRC, CR-UK, European Commission, Gates Foundation, Mayo Foundation, MRC, Royal Society and the Wellcome Trust.To find out more visit https://www.ed.ac.uk/biology/cell-biology

Expected salary

£40247 – 47874 per year

Location

United Kingdom

Job date

Wed, 23 Oct 2024 23:08:54 GMT

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