Postdoctoral Research Associate in Numerical simulations for biomolecular modelling

Job title:

Postdoctoral Research Associate in Numerical simulations for biomolecular modelling

Company

University of Edinburgh

Job description

Job Description:Grade UE07: £40,497 to £48,149 per annumSchool of Mathematics / College of Science and EngineeringFull time: 35 hours per week (100% FTE)Fixed Term: for 24 monthsWe are looking for an outstanding candidate to work on project UNTauANGLE: Untangling the biophysics of tau aggregation through computational modelling, within the School of Mathematics at the prestigious University of Edinburgh, UK.The Opportunity:The aim of the project is to develop and implement a mathematical and numerical modelling framework to understand the fundamental physical processes underlying the dysfunction of the tau protein. The dysfunction of tau, which is tightly linked to a large class of dementias called tauopathies, includes the formation and runaway growth of multi-protein clumps that result in severe damage to neurons. There is still no effective treatment for tauopathies caused by excessive clumping of tau, largely due to an incomplete physical understanding of the molecular interactions and conditions in the neuron that dysregulate tau. The successful applicant, working closely with Dr. Luke Davis, will bring together coarse-grained “minimal” molecular modelling approaches, statistical physics, and high-throughput molecular dynamics computer simulations into a single tau-modelling framework. There is scope for a strong candidate to shape the research direction. The project is funded by the Wellcome Trust, through the Wellcome Accelerator Award (311948/Z/24/Z).Candidates can make informal enquiries about this post by contacting Dr. Luke Davis (luke.davis@ed.ac.uk).Your skills and attributes for success:The appointee has (or soon to have obtained) a PhD in applied mathematics, theoretical biophysics, physics, mathematical biology, or a related discipline. We are particularly encouraging applicants with a strong background in statistical and computational physics, and those with research experience in the modelling of living and active matter. It is essential that you have a demonstrable ability to produce academic writing of the highest quality.Specifically:

• Excellent knowledge of statistical physics and biophysics.
• Experience with molecular dynamics simulations.
• Experience in the efficient running of code on high performance computers.
• Strong coding skills in an object-oriented language.
• Experience with simulation libraries (e.g. LAMMPS) would be highly beneficial.

Click to view a copy of the full (opens new browser tab)Application InformationFor your application, please ensure you include a CV and a
2-page cover letter stating your motivation and suitability for the role. Additionally, please arrange for at least 2 referees to send their reference letters direct to quoting the reference number 12195As a valued member of our team you can expect:

• A competitive salary.
• Access to cutting-edge research facilities and resources.
• Opportunities to collaborate with other researcher groups.
• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community.
• Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our

(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefitsChampioning equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab)The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.Key dates to noteThe closing date for applications is 15th April 2025.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.About Us: As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:The School of MathematicsThe University of Edinburgh’s School of Mathematics is one of the world’s leading mathematical sciences departments, home to world-class researchers and to an innovative educational environment for both undergraduates and postgraduates. We are proud to have a highly international faculty and students from around the world. As a School we value both the breadth and depth of our research and teaching.We have around 110 permanent faculty and around 45 research fellows and research associates, who cover a broad range of research topics in pure and applied mathematics, operational research and statistics. The School has an enviable record of attracting prestigious fellowships and currently hosts, for instance, 6 ERC grant holders and 7 Royal Society University Research and Dorothy Hodgkin Fellows. In the 2023 Shanghai Global Ranking of Academic Subjects we are ranked 18th among the world’s best Mathematics departments. Together with the Departments of Mathematics and Actuarial Mathematics & Statistics at Heriot-Watt University, we form the Maxwell Institute; our joint submission to REF2021was ranked 3rd in the UK for Mathematical Sciences by research power, based on the quality and breadth of our combined research.The School delivers a world-leading educational experience for its students and is constantly exploring new evidence-based ideas in mathematical education in order to provide a stimulating learning environment. There are excellent possibilities for imaginative curriculum development, including online activities, and course design and delivery. The School teaches pure and applied Mathematics, operational research and statistics. We have approximately 1000 undergraduate students, around 210 MSc students, and our Graduate School has close to 160 PhD students.Edinburgh is home to the International Centre for Mathematical Sciences, one of the UK’s two major conference centres in the mathematical sciences and operated jointly by the University with Heriot-Watt University. Over the past 30 years the centre has established a superb reputation for hosting workshops at the highest scientific level on all mathematical topics, attracting many of the best mathematicians in the world to the UK.The School is located in the James Clerk Maxwell Building which is situated on the King’s Buildings campus, approximately 3 kilometres south of the city centre.Further information about the School, our research and our teaching is available on the ( ) (Opens in new browser tab)

Expected salary

£40497 – 48149 per year

Location

United Kingdom

Job date

Thu, 06 Mar 2025 01:17:29 GMT

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