Postdoctoral Research Fellow

Job title:

Postdoctoral Research Fellow

Company

University of Edinburgh

Job description

Job Description:UE07: £39,347 – £46,974 per annumCMVM/Edinburgh Medical School/Deanery of Biomedical Sciences/Centre Discovery Brain SciencesFixed-Term: 36 monthsFull-time: 35 hours per weekWe are looking for a highly motivated Postdoctoral Research Fellow to join the laboratory of Sebastian Greiss at the Centre for Discovery Brain Sciences, University of Edinburgh. The successful candidate will conduct original research at the intersection of synthetic biology and neurobiology, developing and applying state of the art in vivo tools in C. elegans.The Opportunity:We have developed novel optogenetic tools for C. elegans that allow us to functionally dissect the nervous system with single cell precision in freely moving animals. Our approach uses genetic code expansion to incorporate photo-caged non-canonical amino acids site specifically into proteins allowing us to control their activity in situ. We have developed photo-activatable DNA recombinases such as Cre that allow us to switch on expression of target genes including optogenetic channels with single cell precision. For background see: ; .We now apply this technology to investigate, with unparalleled precision, how neuronal circuits generate behaviour. The postdoctoral project will leverage genetic code expansion to generate and apply novel neurobiology tools to study of neural circuits with a single cell resolution.The lab is integrated in the vibrant research environment of the Edinburgh Neuroscience community. The successful candidate will be part of a multi-lab C. elegans research environment at the Centre for Discovery Brain Sciences.Funding is available for three years. The post is full-time (35 hours per week).Your skills and attributes for success:

• A PhD or equivalent degree in neuroscience, synthetic biology or related life-sciences area (awarded or expected)
• Solid background in relevant experimental approaches and methods, such as molecular biology, microscopy and genetics.
• Experience in synthetic biology, neurobiology, or strong expertise in the C. elegans model organism.
• Ability to communicate complex information clearly, orally and in writing

Click to view a copy of the fullAs a valued member of our team you can expect:

• A competitive salary of £39,347 – £46,974 per annum
• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community
• Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our

(opens in a new tab) and use our to discover the total value of your pay and benefitsChampioning equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab)The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.About Us: As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:The Centre for Discovery Brain Sciences (CDBS) explores fundamental physiological mechanisms and pathways, from single genes to complex behaviour.Specific areas of research focus include:

• Neuronal networks, neuroendocrine regulation and adaptive plasticity

• Ion channel physiology, signalling pathways and vesicle trafficking

• Developmental processes including gene regulatory networks and neuro developmental disorders

• Neural development and its relationship to repair

• Cell death and survival

• Neuron-glia interactions

• Hippocampal function, memory storage and retrieval

• Degeneration and dementia

For further information please visit the

Expected salary

£39347 – 46974 per year

Location

Edinburgh – Midlothian

Job date

Sun, 07 Jul 2024 04:53:40 GMT

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