Postdoctoral Researcher

The MRC PPU is based within the School of Life Sciences at the University of Dundee, a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

We are recruiting for an exceptional Postdoctoral Researcher with cutting edge expertise in mass spectrometry to participate to undertake fundamental research to understand the molecular basis of Parkinson’s disease through open and interdisciplinary collaboration. The work will focus on understanding the regulation and function of two protein kinases implicated in Parkinson’s namely LRRK2 and PINK1 and how these enzymes regulate mitochondrial dysfunction

The appointed researcher will be based within the laboratory of Miratul Muqit within the University of Dundee’s MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU, The project forms part of an international collaborative research project that involves significant collaboration with the laboratories of Suzanne Pfeffer and Monther Abu-Remaileh at Stanford University. In addition, there will be opportunity to interact with other laboratories worldwide involved in this initiative. Thi! s project is geared towards deciphering mechanistic biology by which LRRK2 and PINK1 are linked to Parkinson’s disease.< /span>

In your application, please include a covering letter and CV.

Your priorities will include:

  • The initial goals of the project will be to develop mass spectrometry-based methods in proteomics and phosphoprpteomics to study organelle biology

Who we’re looking for:

  • Applicants with at least one first authored publication in a relevant field.
  • Experience and success in studying a signal transduction pathway
  • A strong background in Biochemistry and Molecular Biology
  • Extensive Experience in mass spectrometry

The full-time position will be for an initial 12 months with scope to extend for a further 2 years.

Additional Information

MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU):

The MRC PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation ( . Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC ! PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the d evelopment of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. A key remit of the MRC PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research.

Division of Signal Transduction Unit (DSTT):

The Division of Signal Transduction Therapy (DSTT) was established in 1998. The DSTT is widely regarded as a model for how academia should interact with industry. The DSTT operates as a simple bridging mechanism to enable our PIs working on ubiquitylation and phosphorylation to effectively interact with three major pharmaceutical companies to help accelerate the early stages of drug discovery. The DSTT model enables industrial researchers working in any of the worldwide outlets of three pharmaceutical companies to effectively work with the ~200 Dundee-based researchers that participate in the collaboration to understand the fundamentals of the molecular causes of disease that result from disruptions in protein phosphorylation and ubiquitylation networks.

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