Postdoctoral Researcher-Cancer Biology & Imaging Program

University Health Network -

Full job description

JOB TITLE: Postdoctoral Researcher (PDF)

Job Posting #:920651

Union: Non-Union

Web site: Princess Margaret Most cancers Middle

Division: Most cancers Biology & Imaging Program

Reviews to: Precept Investigator

Hours: 37.5

Wage vary or Wage: To commensurate with expertise and in keeping with UHN compensation coverage

Standing: Short-term Full Time ((1 12 months) with choice to increase past 1 12 months and convert to everlasting place.)

Shifts: N/A

Posted Date: June 1, 2023

Closing Date: Posted Till Crammed

College Well being Community (UHN) is in search of an skilled skilled to fill the important thing position of Postdoctoral Fellow in our Most cancers Biology & Imaging Program

The College Well being Community, the place “above all else the wants of sufferers come first”, encompasses?Toronto Basic Hospital, Toronto Western Hospital, Princess Margaret Most cancers Centre, Toronto Rehabilitation Institute and the Michener Institute of Schooling. The breadth of analysis, the complexity of the instances handled, and the magnitude of its instructional enterprise has made UHN a nationwide and worldwide useful resource for affected person care, analysis and training. With an extended custom of floor breaking firsts and a objective of “Reworking lives and communities by means of excellence in care, discovery and studying”, the College Well being Community (UHN), Canada’s largest analysis instructing hospital, brings collectively over 16,000 staff, greater than 1,200 physicians, 8,000+ college students, and plenty of volunteers. UHN is a caring, inventive place the place wonderful persons are wonderful the world.?

Place Abstract

The DaCosta Analysis Lab on the Princess Margaret Most cancers Centre (PMCC) ( is presently in search of a Postdoctoral Fellow to hitch our preclinical pancreatic analysis crew.

The profitable applicant shall be a part of a analysis group that makes use of intravital fluorescence microscopy imaging in stay animals to check pancreatic most cancers initiation, biology, development, and response to novel radiotherapeutic remedy methods utilizing superior animal fashions of most cancers, inside the mouse pancreas. The profitable applicant will assist to check the pancreatic tumor microenvironment in an orthotopic setting, with a give attention to tumor vasculature, hypoxia, immune cells, stroma, and different key elements in vivo. An essential space to analyze when on this position will embrace the examine of novel radio-sensitizers and their position in pancreatic remedy response. A key extra focus space shall be on the usage of immune- and cell therapies for remedy of pancreatic most cancers.

The profitable applicant may also collaborate extensively with different labs throughout UHN, in addition to exterior collaborators. The place standing is short-term full-time (1 12 months) with the potential to increase to everlasting full-time based mostly on the candidate’s efficiency and compatibility with the analysis crew and lab targets. The best candidate may have a transparent profession plan to turn out to be a principal investigator or impartial scientist in search of an instructional college place.


Carry out rodent microsurgeries to inoculate cells, set up imaging gadgets, or different procedures as obligatory

Intravital imaging of rodent fashions of most cancers utilizing varied methods, together with however not restricted to widefield imaging, confocal and multi-photon microscopy, bioluminescent imaging (BLI), computed tomography (CT), and magnetic resonance imaging (MRI), together with immunohistochemistry and movement cytometry of cells and tissues

Develop and conduct experiments evaluating new most cancers remedy methods, akin to immunotherapies, small-molecule inhibitors, transplantations, and radiation

Suggest new analysis instructions and create tasks

Troubleshoot, consider, and alter protocols as obligatory to enhance knowledge high quality or in response to experimental wants

Keep experimental cell strains and develop new reporter variants as obligatory

Run molecular biology protocols, together with however not restricted to movement cytometry, ELISA, qPCR, and Western Blot

Keep full and correct documentation of information generated and work carried out on behalf of the lab

Adhere to High quality Management and High quality Assurance applications to help the efficient operation of the lab, and to take care of acceptable laboratory requirements

Assist in writing aggressive peer-reviewed analysis grants related to the lab

Write and publish peer-reviewed scientific publications concerning this analysis

Co-supervise graduate and summer season college students with the Principal Investigator and different PDFs


Completion of a doctoral diploma (Ph.D.) from a acknowledged tutorial establishment

Robust background (minimal 5 years) in most cancers biology and immunology, with a publication file, is required

Glorious monitor file of publication productiveness in medium to excessive affect journals within the subject

Monitor file in writing profitable aggressive peer-reviewed analysis grants

Glorious animal dealing with abilities are required

Expertise with animal microsurgery thought of an asset

Robust familiarity with molecular and mobile laboratory methods (e.g., cell tradition, virus transduction, ELISA, movement cytometry, immunohistochemistry) is required

Expertise with in vivo imaging methods, notably confocal and/or multi-photon microscopy is very most popular

Properly-developed laptop abilities and/or the flexibility to study new laptop applications for analyzing imaging knowledge (e.g., IMARIS, HALO, ImageJ) are an asset

Glorious drawback recognition, important considering, organizational, detail-focused, and problem-solving abilities

Means to work independently and as a crew member

Glorious verbal, presentation, and written communication abilities

Expertise in supervising and mentoring undergraduate and/or graduate college students

Expertise in managing analysis tasks successfully, on time and inside price range

Why be part of UHN?

Along with working alongside among the most gifted and galvanizing healthcare professionals on the earth, UHN gives a variety of advantages, applications and perks. It’s the comprehensiveness of those choices that makes it a differentiating issue, permitting you to seek out worth the place it issues most to you, now and all through your profession at UHN.

Aggressive supply packages

Authorities group and a member of the Healthcare of Ontario Pension Plan (HOOPP

Shut entry to Transit and UHN shuttle service

A versatile work atmosphere

Alternatives for improvement and promotions inside a big group

Further perks (a number of company reductions together with: journey, eating places, parking, telephone plans, auto insurance coverage reductions, on-site gyms, and many others.)

Present UHN staff will need to have efficiently accomplished their probationary interval, have a superb worker file together with passable attendance in accordance with UHN’s attendance administration program, to be eligible for consideration.

Vaccines (COVID and others) are a requirement of the job except you’ve got an exemption on a medical floor pursuant to the Ontario Human Rights Code.

UHN is a respectful, caring, and inclusive office. We’re dedicated to championing accessibility, variety and equal alternative. Requests for lodging may be made at any stage of the recruitment course of. Candidates must make their necessities identified prematurely. Any info obtained associated to an lodging shall be addressed confidentially.

College Well being Community thanks all candidates, nonetheless, solely these chosen for an interview shall be contacted.

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