Postdoctoral Researcher in Cancer Genetics and Evolution (Ras pathway)

University of Oxford

About the role

We have an exciting opportunity for a Postdoctoral Researcher to join the research group led by Professor Ian Tomlinson.  The research project focuses on functionally characterising driver mutations in Ras pathway genes that cause the growth of many human cancers, to understand the role and importance of atypical mutations in KRAS, NRAS and BRAF in colorectal and other cancer types. The aim is to explain how atypical mutations differ from their canonical counterparts in terms of mechanisms of pathogenesis and susceptibility to treatment.

You will be responsible for performing molecular, histological and computational analyses of human cancer patients and their tumours, and setting up and working with cell- and animal-based models of cancer.

You will play a central role in the team, managing your own academic research and administrative activities, and co-ordinate multiple aspects of work to meet deadlines. This involves undertaking work as required in human cancers and model systems, to include molecular methods, genomics and transcriptomics, and metabolomics.

The post is offered on a full-time basis until 30th November 2023 in the first instance.

About you

You will hold a PhD/DPhil in a relevant subject, be experienced in the computational and experimental analysis of atypical Ras pathway mutations in human tumours and model systems (especially animal models of colorectal tumorigenesis), and possess computing and data analysis skills, including cancer genome analysis.

You will have the ability to work supportively in a laboratory environment, and to supervise and educate junior co-workers. You will have excellent oral and written communication skills, including proven ability to write at a suitable standard for the preparation of written reports, publications and presentation of work at generalist and specialist levels.  Experience is required in (i) the computational and experimental analysis of atypical Ras pathway mutations in human tumours and model systems, especially animal models of colorectal tumorigenesis, (ii) the assessment, preparation and molecular analysis of archival colorectal cancers, and (iii) the analysis of genomic, transcriptomic and methylomic data from colorectal cancer specimens. A demonstrable publication record of primary scientific papers in cancer genetics, evolution or similar would be highly advantageous.

Application Process

You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae and the names and contact details of two referees as part of your online application.

Only applications received before noon on Friday 23rd June 2023 can be considered.

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