Postdoctoral Scientist, Oxford MND Centre

Job title:

Postdoctoral Scientist, Oxford MND Centre

Firm

College of Oxford

Job description

Postdoctoral Scientist, Oxford MND Centre
Nuffield Division of Scientific Neurosciences (NDCN), John Radcliffe Hospital, Headington, Oxford, OX3 9DUWe’re in search of an enthusiastic postdoctoral researcher seeking to develop an unbiased analysis profession is required for a cutting-edge program of analysis to systematically examine calcium channel antagonists as a category of medicine with potential for illness modification in amyotrophic lateral sclerosis (ALS). A number of members of the category of CCBs will probably be assessed for phenotypical modification and goal engagement throughout a variety of mobile fashions (an ESC-derived motor neuron mannequin of ALS, iPSC-models based mostly on quite a lot of ALS figuring out mutations). Particularly, we intention to 1) Set up whether or not the impact of CCBs (for which we now have preliminary proof) is a category impact, 2) decide the precise targets of calcium channel blockers, which mediate improved survival in our mobile fashions, 3) in collaboration with colleagues in Edinburgh prolong testing to mouse and zebrafish fashions. The final word aim is to pick CCBs for prioritization in experimental drugs research in people with ALS and to develop drug particular biomarkers to be used in these research.A few of your duties will embrace creating, establishing, and pursuing acceptable analytical protocols (cell tradition, imaging, biochemical) and methods to help analysis for the challenge and creating analysis questions, testing hypotheses and analysing scientific knowledge from quite a lot of sources, reviewing and refining working hypotheses as acceptable. In addition to supervision of graduate college students, appearing as a supply of data and recommendation to different members of the group on scientific protocols and experimental methods, liaison with collaborators and handle personal educational analysis and administrative actions. This includes small scale challenge administration, to co-ordinate a number of facets of labor to satisfy deadlines.It’s important that you just maintain or be near award of a doctorate (PhD/DPhil) in Neuroscience, have a confirmed monitor report in cell tradition (notably iPSC and ESC-derived neuronal cell tradition) and expertise in molecular biology methods.It’s fascinating that you’ve got expertise of analysis in neurodegeneration and expertise of grant purposes.Please see the beneath ‘Job Description’ for additional particulars on the tasks and choice standards, in addition to additional details about the college and easy methods to apply.The put up is full time, fastened time period till twenty seventh March 2027Solely purposes acquired earlier than 12.00 noon on Wednesday twenty fourth April will probably be thought-about.Interviews will probably be held as quickly as attainable thereafter.Contact Particular person : NDCN HR Recruitment Emptiness ID : 172135
Contact Cellphone : Closing Date & Time : 24-Apr-2024 12:00
Pay Scale : STANDARD GRADE 7 Contact E mail :
Wage (£) : £33,309 – £40,927 every year. A much less skilled candidate could also be appointed at Grade 6 (£32,332 – £38,205 every year), with a commensurate adjustment in both the important standards, tasks or duties.

Anticipated wage

Location

Oxford

Job date

Fri, 05 Apr 2024 02:05:06 GMT

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