Postdoctoral Scientist – Structural Studies – Dr Tanmay Bharat – LMB 2248

Medical Research Council

View Emptiness — Postdoctoral Scientist – Structural Research – Dr Tanmay Bharat – LMB 2248
Open Date
18/09/2023, 10:00
Shut Date
16/10/2023, 23:55

MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is likely one of the birthplaces of recent molecular biology and has performed an essential position within the growth of many new methods, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a transparent aim of understanding organic processes on the molecular stage, with the final word purpose of utilizing this information to sort out particular issues in human well being and illness. We purpose to sort out tough, long-term issues, which frequently require funding over a few years.

There are 4 scientific Divisions – Structural Research, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. Nevertheless, scientific collaboration between the completely different Divisions is in depth. Scientists are nicely supported by wonderful scientific services and by the LMB Operations Group which maintains the core infrastructure and companies of the institute.

The LMB supplies an unsurpassed atmosphere for each new and established researchers. Scientists are drawn to the LMB from everywhere in the world, thus making a full of life and worldwide neighborhood for the trade of concepts and technical innovation.

UK Analysis and Innovation is a brand new entity that brings collectively 9 companions to create an unbiased organisation with a powerful voice for analysis and innovation, extra data will be discovered at

MRC – 4


£35,143 each year

Fastened Time period


Full Time

2 years

General objective: 
To work throughout the group of Dr Tanmay Bharat (MRC Laboratory of Molecular Biology, LMB) on a programme aimed toward computational inhibitor growth in opposition to biofilms of pathogenic micro organism. This submit is a collaboration with Drs. Juan Carlos Mobarec and Maria Flocco (AstraZeneca, AZ) to undertake analysis to develop and apply cutting-edge software program instruments for utilising in situ structural biology knowledge for inhibitor binding web site prediction, inhibitor (together with antibody) design utilizing computational simulations and structure-based drug discovery strategies. Being a detailed collaboration between the LMB and AZ will be certain that experience and infrastructure from academia and business is out there to finish this thrilling mission.
Important duties:
•    To undertake analysis aimed toward inhibitor (together with antibody) web site prediction in opposition to bacterial biofilm targets with the top aim of novel inhibitor design.
•    To determine, develop and apply a broad vary of methods to pursue the analysis goals.
•    To current scientific work at seminars throughout the laboratory and at exterior conferences.
•    To contribute to laboratory-wide discussions on developments throughout the subject. 
•    To draft scientific papers, and contribute to the general preparation of analysis for publication.
•    To contribute to the LMB and AZ’s mission within the public engagement of science, and the interpretation of analysis findings into enhancements in well being care.
•    To help within the coaching of PhD college students and different members of the LMB and AZ.
Key duties:
Inside the general route of the programme, the teams, the remit of the mission and in dialogue with the Group Chief, you’ll make a big enter into figuring out the route of the mission inside a two 12 months lifespan. 
To plan your individual work and goals on a 12-month foundation and handle your experimental work throughout the mission alongside along with your supervisors.
To work with restricted supervision to determine, develop, modify and apply the required methods to attain the objectives of the mission.
To introduce and apply new methods throughout a variety of disciplines and to have the creativity and initiative to develop novel approaches and strategies the place required.
To make sure the analysis is carried out in accordance with good observe and in compliance with native insurance policies and authorized necessities.
To contribute to the graceful working of the group, together with the efficient use of sources, coaching of others and taking duty to be used of communal services.
To boost your analysis and generic abilities by a tailor-made growth programme. 
Working relationships:  
You’ll report back to Drs Tanmay Bharat, Juan Carlos Mobarec and Maria Flocco and you’ll work together and collaborate with different Postdoctoral Scientists, Analysis Help employees and college students, not solely in your group, but additionally throughout the LMB, AZ and with exterior teams as obligatory.
Extra data:
This can be a two-year coaching and growth place for a Postdoctoral Scientist who has lately accomplished their doctoral research, is shifting into a brand new analysis self-discipline or has restricted expertise of key transferable abilities. We help Postdoctoral Scientists with a spread of formal and on-the-job coaching, together with:
•    MRC coaching programs.
•    Exterior coaching and private growth programs.
•    One-to-one coaching along with your Supervisor and different Scientists.
You’ll decide to endeavor the next:
•    Growing and following a private growth plan.
•    Attending coaching programs.
•    Figuring out extra coaching which can help you to develop your profession. 

Tutorial {qualifications}: 
These ought to embrace a PhD in a related topic or as a consequence of full PhD inside 6 months.
Technical abilities and experience:
Expertise of and skill to carry out methods related to the mission.  Significantly helpful can be hands-on expertise of computational structural biology, computational chemistry, structural bioinformatics, or laptop science with give attention to machine studying/AI. 
Observe file of analysis:
This may embrace achievements, and contributions to printed papers.

Different related proof of:
•    Dedication.
•    Originality.
•    Potential to speak.
•    Working with others.
Extra data: 

We’re in search of a person who’s motivated to develop and apply software program instruments that will probably be used for drug growth and inhibitor design in opposition to bacterial pathogens. There may be additionally scope to be taught experimental methods within the laboratory or carry out knowledge assortment on electron microscopes relying on the pursuits of the appropriate candidate.
This submit is funded as a part of the Blue Sky Collaboration between the LMB and AZ and is a part of mission BSF2-11, “In situ structural and practical research of bacterial biofilm inhibition”, by Tanmay Bharat, Juan Carlos Mobarec and Maria Flocco. The ensuing mental property will probably be owned by the LMB and there will probably be no impediments to publishing outcomes. The computational work will probably be carried out primarily at AZ, with shut help from Tanmay Bharat’s staff on the LMB. Experimental work will probably be accomplished primarily on the LMB, with mental contributions each collaboration companions to the mission.

Company/Native duties & necessities

You should always perform your duties with due regard to the UKRI: 
•    Code of Conduct
•    Equality, Range and Inclusion coverage
•    Well being and Security coverage
•    Information Safety coverage
Job descriptions must be reviewed frequently and on the annual appraisal.  Any adjustments must be made and agreed between you and your supervisor.
The above lists usually are not exhaustive and you might be required to undertake such duties as could fairly be requested throughout the scope of the submit.  All workers are required to behave professionally, co-operatively and flexibly in step with the necessities of the submit, the MRC and UKRI.  
The position holder will probably be required to have the suitable stage of safety screening/vetting required for the position. UKRI reserves the fitting to run or re-run safety clearance as required in the course of the course of employment.

The MRC is a superb place to work and progress your profession, be it in scientific analysis or the help features.The MRC is a novel working atmosphere the place our researchers are rewarded by world class innovation and collaboration alternatives that the MRC identify brings. The MRC is a wonderful place to develop your self additional and a spread of coaching & growth alternatives will probably be obtainable to you, together with skilled registration with the Science Council.
Selecting to come back to work on the MRC (a part of UKRI) implies that you should have entry to an entire host of advantages from an outlined profit pension scheme and wonderful vacation entitlement to entry to worker purchasing/journey reductions and wage sacrifice cycle to work scheme, in addition to the prospect to place the MRC and UKRI in your CV sooner or later.
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We’ll conduct a full and complete pre-employment test as a necessary a part of the recruitment course of on all people which can be supplied a place with UKRI. This may embrace a safety test and an excessive organisations affiliation test.  The position holder will probably be required to have the suitable stage of safety screening/vetting required for the position.  UKRI reserves the fitting to run or re-run safety clearance as required in the course of the course of employment.

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