Principal Scientist

Job title:

Principal Scientist

Firm

GlaxoSmithKline

Job description

Principal ScientistClosing Date for Purposes – fifteenth April (COB)This can be a site-based function at Stevenage.We’re on the lookout for a extremely motivated, versatile and skilled scientist to affix the Mobile Biomarkers Circulation Cytometry workforce inside Biomarker & Bioanalytical Platforms within the Precision Drugs division positioned in Stevenage, UK.The workforce is chargeable for the event and validation of complicated multi-parameter circulate cytometry panels and subsequent software of those panels to scientific trial pattern evaluation. The deep immunophenotyping information generated by these biomarker panels helps us to guage illness heterogeneity, drug-target engagement, drug mechanism of motion and affected person responses.The profitable candidate could have a deep understanding of immunology and can act as a circulate cytometry technical professional, supporting excessive parameter deep immunophenotyping of immune cell subsets in addition to receptor occupancy endpoints. This can be a lab-based function and can embrace all facets of circulate cytometry technique improvement and optimisation, validation and pattern evaluation for scientific research throughout all the GSK portfolio.This function will likely be chargeable for completion of all facets of assay workflow together with reagent choice, pattern preparation, pattern acquisition, information evaluation, interpretation and presentation. As well as, this function will guarantee all work is carried out in compliance with GCP rules together with adherence to the suitable SOPs.We create a spot the place individuals can develop, be their finest, be protected, and really feel welcome, valued and included. We provide a aggressive wage, an annual bonus based mostly on firm efficiency, healthcare and wellbeing programmes, pension plan membership, and shares and financial savings programme.We embrace fashionable work practises; our Efficiency with Alternative programme provides a hybrid working mannequin, empowering you to seek out the optimum stability between distant and in-office work.Uncover extra about our firm vast advantages and life at GSK on our webpageOn this function you’ll:

• Generate prime quality information to assist scientific research by spectral circulate cytometry (Cytek Aurora)
• Conduct and oversee all facets of technique improvement, troubleshooting, validation and pattern evaluation for scientific research.
• Deal with human organic samples and carry out experimental work in accordance with GCP rules, security assessments and information integrity pointers.
• Ship, interpret and talk complicated scientific information to challenge/program groups inside agreed timelines while managing a number of tasks concurrently.
• Assist lead efforts to analyze novel cytometry and information evaluation platforms and embed them inside the organisation.
• Perform properly in a workforce and possess an excellent stability of artistic and analytical abilities. Be prepared to develop and practice others as required.

Why you?{Qualifications} & Abilities:We’re on the lookout for professionals with these required abilities to attain our objectives: This function requires a PhD in Immunology or a associated area with post-PhD expertise in immunology, cell biology, biomedical science, or associated disciplines. Or sturdy expertise in Business in an identical area having gained an undergraduate diploma in one of many disciplines named above.

• Robust immunological information enabling phenotyping of a number of cell lineages with in-depth theoretical and sensible understanding of circulate cytometry (expertise in design and execution of 16+ color circulate cytometry panels).
• Robust laboratory expertise and experience working with a wide range of pattern sorts together with complete blood, PBMC and single-cell tissue suspensions which can be contaminated with blood borne pathogens reminiscent of HBV.
• Appreciable expertise in the usage of circulate cytometry evaluation software program (OMIQ most well-liked) with good consideration to element, glorious oral and written communication abilities.
• Potential to keep up a disciplined strategy, guaranteeing a relentless concentrate on high quality, compliance, and operational excellence even when flexing between a number of tasks.
• Be a extremely motivated workforce participant with the flexibility to work together successfully inside a multi-disciplinary workforce but additionally the arrogance to work independently to tight deadlines.
• Common sense and resolution making, particularly for prioritising a number of requests with the flexibility to drawback resolve and troubleshoot.

Most well-liked {Qualifications} & Abilities:If in case you have the next traits, it will be a plus:

• A great understanding of the drug improvement course of
• Expertise in design and execution of twenty-two+ color circulate cytometry panels, together with receptor occupancy assays.
• Robust laboratory expertise and understanding of scientific and non-clinical circulate cytometry biomarker assay improvement, validation and implementation with firsthand sensible expertise with the Cytek Aurora.
• Direct expertise with high-dimensional information evaluation (e.g. tSNE, UMAP, CITRUS, FlowSOM).
• Expertise of know-how switch of circulate cytometry assays to Contract Analysis Organisations.
• Expertise of writing SOPs and different regulated paperwork.

Why Us?GSK is a worldwide biopharma firm with a particular goal – to unite science, know-how and expertise to get forward of illness collectively – so we will positively impression the well being of billions of individuals and ship stronger, extra sustainable shareholder returns – as a corporation the place individuals can thrive. Getting forward means stopping illness in addition to treating it, and we intention to positively impression the well being of two.5 billion individuals by the tip of 2030.Our success completely is determined by our individuals. Whereas getting forward of illness collectively is about our ambition for sufferers and shareholders, it’s additionally about making GSK a spot the place individuals can thrive. We wish GSK to be a office the place everybody can really feel a way of belonging and thrive as set out in our Equal and Inclusive Remedy of Workers coverage. We’re dedicated to being extra proactive in any respect ranges in order that our workforce displays the communities we work and rent in, and our GSK management displays our GSK workforce.As an Equal Alternative Employer, we’re open to all expertise. Within the US, we additionally adhere to Affirmative Motion rules. This ensures that every one certified candidates will obtain equal consideration for employment with out regard to neurodiversity, race/ethnicity, color, nationwide origin, faith, gender, being pregnant, marital standing, sexual orientation, gender id/expression, age, incapacity, genetic data, army service, coated/protected veteran standing or some other federal, state or native protected class*(*US solely).We consider in an agile working tradition for all our roles. If flexibility is necessary to you, we encourage you to discover with our hiring workforce what the alternatives are.Must you require any changes to our course of to help you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please be aware ought to your enquiry not relate to changes, we will be unable to assist you thru these channels. Nonetheless, we have now created a UK Recruitment FAQ information. Click on the and scroll to the Careers Part the place you can find solutions to a number of questions we obtain .As you apply, we are going to ask you to share some private data which is completely voluntary. We need to have a chance to think about a various pool of certified candidates and this data will help us in assembly that goal and in understanding how properly we’re doing towards our inclusion and variety ambitions. We’d actually admire it in case you may take just a few moments to finish it. Relaxation assured, Hiring Managers should not have entry to this data and we are going to deal with your data confidentially.Essential discover to Employment companies/ BusinessesGSK doesn’t settle for referrals from employment companies and/or employment businesses in respect of the vacancies posted on this website. All employment companies/businesses are required to contact GSK’s industrial and common procurement/human sources division to acquire prior written authorization earlier than referring any candidates to GSK. The acquiring of prior written authorization is a situation precedent to any settlement (verbal or written) between the employment enterprise/ company and GSK. Within the absence of such written authorization being obtained any actions undertaken by the employment enterprise/company shall be deemed to have been carried out with out the consent or contractual settlement of GSK. GSK shall subsequently not be responsible for any charges arising from such actions or any charges arising from any referrals by employment companies/businesses in respect of the vacancies posted on this website.Please be aware that in case you are a US Licensed Healthcare Skilled or Healthcare Skilled as outlined by the legal guidelines of the state issuing your license, GSK could also be required to seize and report bills GSK incurs, in your behalf, within the occasion you might be afforded an interview for employment. This seize of relevant transfers of worth is important to make sure GSK’s compliance to all federal and state US Transparency necessities. For extra data, please go to GSK’s Transparency Reporting website.

Anticipated wage

Location

Stevenage, Hertfordshire

Job date

Tue, 02 Apr 2024 04:45:45 GMT

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