Principal Scientist

Job title:

Principal Scientist

Company

GlaxoSmithKline

Job description

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpagePrincipal ScientistWe are seeking a motivated and experienced Bioanalyst to join our group based at our flagship R&D site in Stevenage, Hertfordshire. The team supports soluble biomarker measurements for clinical studies using a variety of ligand binding assay techniques. The data we generate is critical to helping GSK Project Teams make decisions on progressing new molecules towards becoming medicines.Job PurposeIn this role you will independently develop and validate bespoke immunoassays for soluble biomarker endpoints in support of clinical studies. You will be responsible for the delivery of high-quality bioanalytical assay data to study teams for early stage clinical studies (e.g. enabling and FTiH). You will also be required to act as a subject matter expert in support of our CRO partners, working to ensure that assay transfers proceed smoothly prior to later stage clinical studies.We are looking to for this role to be based at Stevenage site only.In this role you will…

• Provide scientific leadership and set strategic direction on emerging technologies
• Build effective relationships with the various supported groups within and outside the department to balance stakeholder expectations with scientific quality and validation requirements ensuring limitations of assays and data are well understood
• Holding yourself accountable for delivering high quality bioanalytical results, managing timelines whilst being fully compliant with GCP regulatory requirements
• Adopt a technology agnostic attitude and openness to analytical techniques when planning support for all modalities
• Work as part of the team to ensure day-to-day laboratory responsibilities are met (QC checking, reviewing study plans/reports etc)
• Drive the departments “automation first” objective for both the laboratory work and the pre-analytical and post-analytical workflows
• Partner with external companies, institutes and consortium to meet departmental objectives
• Well-connected in the analytical community established through publications and presentations at national and international conferences
• Drive innovation and actively contribute to process improvements (scientific, regulatory/quality)

Why you?Basic Qualifications/Experience:We are looking for professionals with these required skills to achieve our goals:

• Graduate degree in biology, biochemistry or pharmacology
• Extensive experience running Bioanalytical or Biomarker studies in a GxP regulated environment with a focus on good record keeping and data integrity
• Experience in the method development and validation of quantitative immunoassays using one or more of the following Gyrolab, MSD, Simoa, SMCxPRO, ELLA
• Ability to effectively manage multiple priorities, communicate recommendations clearly and enjoy working within a team
• Ability to present both written and oral communications to R&D stakeholders

Preferred Qualifications:If you have the following characteristics, it would be a plus:

• PhD degree in biology, biochemistry or pharmacology
• Understanding of regulatory aspects of human biological sample management, Good Clinical Practice (GCP)
• Experience of interacting with LabQA/regulatory inspectors
• Experience in tailoring bespoke biomarker assay validations to the context of use for the data
• Experience with automated liquid handling platforms (e.g. Labcyte Echo, SPT Labtech DragonFly, Agilent BRAVO, Hamilton STAR)
• Experience using Thermo Watson LIMS

Closing Date for Applications: Thursday 19th September 2024Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.GSK R&DAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receive .As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.

Expected salary

Location

Stevenage, Hertfordshire

Job date

Sat, 31 Aug 2024 05:01:05 GMT

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