Principal Scientist, P&PA R&D

Job title:

Principal Scientist, P&PA R&D

Firm

Lonza

Job description

Immediately, Lonza is a worldwide chief in life sciences working throughout three continents. Whereas we work in science, there’s no magic components to how we do it. Our biggest scientific answer is proficient folks working collectively, devising concepts that assist companies to assist folks. In alternate, we let our folks personal their careers. Their concepts, massive and small, genuinely enhance the world. And that’s the type of work we need to be a part of.Function Goal:We’re presently seeking to recruit a Principal Scientist to hitch the Protein Chemistry group inside the Protein and Course of Analytics (P&PA) R&D crew. We’re searching for a extremely motivated particular person with a proved document in analytical innovation, examine design, methodology growth and knowledge evaluation targeted in Protein Chemistry & Characterisation (Mass Spectrometry). Working inside this crew, you can be delivering high-value technical innovation each through analytical tasks and as a part of a wider collaborative challenge crew. This high-level scientific place requires in depth expertise within the space of analytical separation and characterization of biotherapeutic proteins, with key concentrate on protein characterisation by MS-based methods. Minimal necessities embrace industrial expertise with MS characterisation of proteins (peptide mapping, intact and native MS evaluation), and completely different chromatography and separation strategies (IEX, SEC, RP, HIC, HILIC, LC-MS, LC-MS/MS, icIEF, CE-SDS) for evaluation of related protein CQAs (e.g. cost/ measurement variant evaluation, glycosylation profile, purity, PTMs). It additionally requires potential to investigate and interpret complicated knowledge and to develop, optimise and troubleshoot analytical strategies making use of a QbD method. The incumbent will probably be liable for oversight and execution of the scientific actions of the crew, which can embrace parts of laboratory work, scientific overview and training, challenge management & administration, skilled mentoring, expertise scouting and driving implementation of latest applied sciences inside the Lonza community.Key Accountabilities and Duties:Offering oversight and execute scientific actions with parts of examine design and implementation, laboratory work, scientific overview, teaching of junior scientists, challenge management & administration, skilled mentoring, expertise scoutingAnalysis and growth of revolutionary Protein characterisation strategies and workflows to assist biologics course of growthPerforming expertise scouting and driving implementation of latest applied sciences and software program inside the Lonza communityOffering scientific management and route inside the crew and main robust collaboration efforts throughout the Bio R&D division to maximise synergies and impressionParticipating in exterior collaborations and disseminating outcomes by means of publications and participation to excessive profile conferences and workshopsAct as a Protein Characterisation (MS) SME in a number of collaborative tasks at a time, having the ability to information analytical discussions, translate knowledge into the challenge context and assist challenge choice making{Qualifications} and Required Expertise:PhD Diploma in Life Sciences/ Science or equal; Most well-liked space of examine: Biochemistry/ Biomanufacturing/ BiotechnologyIntensive business expertise (5+ years) in an analytical laboratory targeted in MS methodology growth and Protein Characterisation by Mass Spectrometry approachesDetailed data and sensible utility of liquid chromatography (SEC, IEX, HILIC, HIC, RP, affinity), mass spectrometry (LC-MS, LC-MS/MS), different separation strategies (icIEF, CE-SDS) for protein evaluation, and QbD for methodology growthThorough understanding of the cutting-edge applied sciences and its purposes for protein evaluation, together with cost and measurement variant evaluation, titer measurement, glycosylation evaluation, product associated impurities and willpower of post-translational modifications (PTMs)Expertise with a wide range of protein codecs, e.g. mAbs, bispecific Abs, fusion proteins and sophisticated glycoproteinsAnalysis targeted, with a eager curiosity in innovation inside the biologics spaceAn excellent basic background in established analytical strategies inside the business, together with the strengths and weaknesses of assorted approachesDocumented historical past of high-quality publications / patent filings within the area of Protein ChemistryWonderful communication and interpersonal abilities, with the power to straight affect stakeholders in a scientific capability, and to ship technical tasks inside a matrix groupMind for scoping and design of complicated tasks.Excessive stage of empathy and want to see others succeedConfirmed potential to ship revolutionary options to scientific challenges, inside particular timelines and outlined success standardsResilient to setbacks and capable of inspire self and others beneath difficult situationsPotential to take calculated dangersEach day, Lonza’s services have a constructive impression on thousands and thousands of individuals. For us, this isn’t solely a fantastic privilege, but in addition a fantastic accountability. How we obtain our enterprise outcomes is simply as vital because the achievements themselves. At Lonza, we respect and defend our folks and the environment. Any success we obtain is not any success in any respect if not achieved ethically.Individuals come to Lonza for the problem and creativity of fixing complicated issues and creating new concepts in life sciences. In return, we provide the satisfaction that comes with enhancing lives all all over the world. The satisfaction that comes with making a significant distinction.

Anticipated wage

Location

Slough, Berkshire

Job date

Fri, 08 Mar 2024 01:49:49 GMT

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