Principal Scientist, Quantitative Systems Toxicologist – Non-Clinical Safety

Job title:

Principal Scientist, Quantitative Systems Toxicologist – Non-Clinical Safety

Company

GlaxoSmithKline

Job description

Principal Scientist, Quantitative Systems Toxicologist – Non-Clinical SafetyThe R&D Non-Clinical Safety (NCS) organisation is accountable for driving human-relevant hazard detection, risk characterisation and quantitative safety translation to advance the next generation of medicines to patients.The NCS organisation requires modelling expertise (i.e., Quantitative Systems Toxicology (QST) and machine learning) to contribute to transforming GSK’s approach towards predicting adverse drug reactions and the establishment of leading NCS platforms to evaluate the safety of new medicines.We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practices; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpageIn this role you willDesign and implement QST approaches to aid investigation of drug safety questions to enhance mechanistic understanding and provide translational risk assessmentProvide consultancy and training in understanding quantitative systems toxicology approaches across NCS and R&DProvide direction on generating non-clinical experimental model input data, embedding established modelling approaches and contextualisation of modelling outputs (in conjunction with conventional Non-Clinical toxicology endpoints)Work with internal and external partners to guide development and deployment of new QST modelsIdentify and implement state-of-the-art machine learning and statistical approaches to assist in the interpretation of cellular and molecular assay outcomesWork collaboratively, establish and maintain close working relationships with R&D modellers, data scientists and NCS biological scientists with contributions to experimental study designs to support relevant modelling approachesProduce high quality written documentation of methodologies applied (e.g. protocol contributions, scope of work), analysis results and interpretation for internal decision making purposes and inclusion in regulatory submissions as requiredWhy you?Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:PhD relevant in Mathematics, Physics, Engineering, Statistics, Computational Biology, Scientific Computing or related fieldAbility to work collaboratively in multidisciplinary environment with good communication skillsExpertise in scientific computing and programming – such as R, Python, MATLABExperience of using quantitative mathematical modelling approaches linking mechanistic drug disposition and toxicology/pharmacology endpoints to support the progression of drug discovery and development programmesExperience in applying mechanism based mathematical modelling techniques and machine learning approaches in the life sciencesCore competency in numerical analysis focusing on differential equations and parameter optimisationClosing Date for Applications – June 23rd, 2024 (COB)Please take a copy of the Job Description, as this will not be available post closure of the advert.When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receiveAs you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.

Expected salary

Location

Stevenage, Hertfordshire

Job date

Sun, 09 Jun 2024 03:18:20 GMT

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