Proteomics/Mass Spectrometry Technician

Job id: 081885. Wage: ​​​£37,332 – 42,099​​ each year, together with London Weighting Allowance.

Posted: 03 January 2024. Deadline: 30 January 2024.

Enterprise unit: Analysis Platforms. Division: Proteomics.

Contact particulars:​Steven Lynham. [email protected]

Location: Denmark Hill Campus. Class: Skilled & Assist Providers.

Job description

We’re on the lookout for an skilled Proteomics/Mass Spectrometry Technician to hitch the Proteomics Facility at King’s School London, Denmark Hill Campus.

The Proteomics Facility specialises in peptide and protein evaluation utilizing mass spectrometry. It provides a variety of providers, from protein identification to post-translational modification evaluation and quantification.

Our mission is to advance organic understanding and practice the subsequent technology of researchers on this very important subject.

The aim of the function is to offer technical help and assist to proteomic initiatives from King’s School London researchers and exterior organisations. This consists of operation and upkeep of the Thermo Scientific Tribrid Orbitrap mass spectrometer, pattern preparation, knowledge evaluation and administration, report writing and day-to-day operation of normal lab gear within the facility, beneath the steerage of the Facility Supervisor and Deputy Supervisor.

The profitable candidate will ship assist in an organised, well timed and environment friendly method and be capable of handle and prioritise their very own workload. Robust commutation abilities are a key facet of the function, and the profitable candidate might want to talk successfully with purchasers, colleagues, and exterior companions.

This function provides alternatives for growth and progress and the power is dedicated to supporting workers to succeed in their profession aspirations.

This put up can be supplied on an ​indefinite contract​.

This can be a ​full-time put up​ – ​100​% full time equal.

Key duties

• Present a wonderful service in mass spectrometry-based proteomics to world famend researchers at King’s School London and exterior organisations.

• Means to work with a excessive diploma of independence in addition to a part of a small group beneath the steerage of the Facility Supervisor.

• Apply important data and expertise for pattern preparation of complicated samples utilizing a wide range of pattern varieties (e.g., cell lysates, plasma, serum, cerebrospinal fluid, and tissue biopsies) to good laboratory observe.

• In a position to apply technical data and experience to develop strategies to attain one of the best from samples and determine the optimum technique to carry out evaluation.

• Have in depth data of contemporary state-of-the-art mass spectrometry and nanoflow liquid chromatography with the power to undertake technique growth of latest and present strategies for peptide/protein identification, post-translational modification evaluation and quantitative proteomics on a worldwide scale utilizing present peptide labelling applied sciences.

• Carry out knowledge evaluation and interpret outcomes, speaking these to the researcher concisely by report writing, conferences and shows together with common suggestions to the researcher on the progress of their pattern preparation and evaluation.

• Present technical help with troubleshooting of kit as and when it wanted.

• Carry out routine laboratory duties together with the use and upkeep of normal laboratory gear, organising and ordering consumables, cataloguing samples, and protein database administration.

• In a position to prioritise initiatives with consideration to element and plan personal workload to make sure supply of agreed deadlines.

• Assist the Supervisor and Deputy Supervisor of their day-to-day accountability for the protected administration and operation of the power, as outlined within the facility’s well being and security native guidelines, together with having data of native, RMID and college security insurance policies and procedures, related authorized necessities and data of the services hazards and management measures. The work will contain the usage of chemical substances, delicate and costly electrical gear, and heavy gear, all of that are doubtlessly hazardous. All of those require acceptable management measures and data of ordinary working procedures. Extended durations of focus and the usage of show display gear are additionally concerned.

• Consciousness of sustainable lab practices and proactive in figuring out alternatives to function extra sustainably, together with engagement with LEAF and My Inexperienced Lab.

• Undertake another cheap job inside the Facility as requested by the Facility Supervisor.

The above checklist of duties will not be exhaustive, and the put up holder can be required to undertake such duties and duties as might fairly be anticipated inside the scope and grading of the put up.

Expertise, data, and expertise

Important standards

BSc/MSc, or equal expertise in Chemistry, Biochemistry, or associated topic with sensible expertise of working in a proteomics laboratory in a tutorial or trade setting.

Glorious technical data of Orbitrap Tribrid MS gear and nano liquid chromatography or related high-end mass spectrometers.

Glorious data of mass spectrometry knowledge evaluation, knowledge interpretation and computational strategies utilizing software program similar to Proteome Discoverer, MaxQuant, Peaks Scaffold and so forth.

Expertise within the preparation of organic samples to a excessive commonplace.

Expertise of calibration and troubleshooting technical issues with MS and LC & UHPLC chromatography programs.

Glorious planning and organisational abilities, with the power to handle competing priorities.

Detailed and centered method, means to report and handle knowledge precisely, and in accordance with GDPR and laws necessities.

Robust commutations abilities and talent to speak successfully with colleagues, purchasers, and trade companions.

Good understanding of Well being and Security practices in a laboratory setting and data of authorized necessities and related insurance policies, together with the Human Tissue Authority Laws and COSHH.

Fascinating standards

Familiarity or experience in R, python, or related languages.

In a position to reveal broad biology and proteomic abilities.

This put up is topic to Occupational Well being clearance.​