Quality Control Scientist

Job title:

Quality Control Scientist

Company

King’s College London

Job description

The King’s College London Gene Therapy Vector Facility (GTVF) provides comprehensive GMP-grade viral vector manufacturing services. This includes Lentiviral Vector (LV), Retroviral Vector (RV) and Adeno-Associated Viral Vector (AAV) production for early-phase clinical trials, alongside substantial programmes in process innovation, knowledge transfer and training to address critical skills shortages.​In partnership with the Network of Innovation Hubs, our vision is to ensure that the UK capitalises on its outstanding academic medical research to deliver novel gene therapies to patients, providing transformative treatments for currently intractable conditions, and generating a vibrant economic landscape.​The GTVF is run by a large, industry-leading team of >50 people who have extensive experience in delivering end-to-end viral vector manufacture for both academic and commercial clients, with a focus on early-stage clinical trials.​About the roleThe Cell and Gene Therapy, King’s (CGT-K) group manufactures a variety of Advanced Therapy Medicinal Products (ATMPs) and starting materials, in state-of-the-art Good Manufacturing Practice (GMP) facilities for treatment of cancer and rare diseases. This post supports the translation of cutting-edge medical research into clinical application. The position is based in a team with an excellent track record in both basic and translational research.The Quality Control Scientist will be responsible for the carrying out in-house quality control (QC) testing of cell and gene therapy products manufactured by CGT-K group for clinical trials or as starting materials for use in the further manufacturing of ATMPs. Assays will include but not be limited to; flow cytometry-based assays, cell proliferation assays, protein assays and western blots and molecular based methods e.g., qPCR. The role holder will also support the development, validation and establishment of a broad range of state-of-the-art new in-house QC assays and will work with external collaborators on the technical transfer of QC assays into the CGT-K group. The QC Scientist will be responsible for maintaining an inventory of QC samples and will assist with the sending QC samples to external laboratories for testing and ensuring the testing results are received in a timely manner.The role holder will also play a critical role in conducting immune monitoring studies as part of in-house early phase clinical trials of cell-based immunotherapies.Testing of in-coming materials and participating in the routine environmental monitoring of the GMP facilities will also form part of the day-to-day activties of the role.The work carried out by the QC Scientist must be undertaken in compliance with regulatory requirements and quality standards including those of ICH, ISO, GMP and Good Laboratory Practice.The Quality Control Scientist will be an integral member of the QC team and work with team members across the whole of the Cell and Gene Therapy group including R&D, Production, Technical and Quality Assurance. The QC Scientist will be responsible to the Head of Quality.This position provides an opportunity to develop a good understanding of a wide range of cell and gene therapy product analytical assays and QC testing within the medicines manufacturing field. The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.This is a full time post (35 hours per week), and you will be offered an indefinite contract.About youTo be successful in this role, we are looking for candidates to have the following skills and experience:Essential criteria * Degree in one of the Biological Sciences or related discipline

• Knowledge and understanding of a wide range of analytical assays including Enzyme-linked- Immunosorbent-Assay (ELISA), Protein Assays, Cell-based Flow Cytometry and qPCR
• Demonstrated Quality Control (QC) experience (sample preparation, sample analysis/testing, data entry and review)
• On-hands laboratory-based experience of Flow Cytometry, qPCR, mammalian cell culture
• Ability to prioritise workloads in response to changing demands and requirements. Able to take initiative and work without direct supervision
• Experience of working to GMP or Good Laboratory Practice (GLP) in an academic setting biotechnology/pharmaceutical company or Hospital
• Ability to follow detailed written standard operation procedures and verbal instructions. Good attention to detail

Desirable criteria * Ability to write unambiguous comprehensive experimental protocols

• Hands-on experience of microbiological environmental monitoring

Downloading a copy of our Job DescriptionFull details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.Further informationWe pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King’s.We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.To find out how our managers will review your application, please take a look at our ‘ ‘ pages.Interviews are due to be held on the week commencing 24th July 2024.We are not able to offer sponsorship for candidates who do not currently possess the right to work in the UK.CompanyKing’s College London is one of the top 20 universities in the world and among the oldest in England. King’s has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.King’s has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.King’s has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.King’s College London and Guy’s and St Thomas’, King’s College Hospital and South London and Maudsley NHS Foundation Trusts are part of King’s Health Partners. King’s Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world’s leading research-led universities and three of London’s most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: .King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at .Company info Mini-site Telephone +(44)02078365454 Location STRAND
LONDON
WC2R 2LS
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Expected salary

£37332 – 38966 per year

Location

Central London

Job date

Wed, 26 Jun 2024 01:12:56 GMT

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