UNIVERSITY OF SURREY
18 Nov 2023
- UNIVERSITY OF SURREY
- Analysis Subject
- Pc science
- Researcher Profile
- Recognised Researcher (R2)
First Stage Researcher (R1)
- United Kingdom
- Utility Deadline
- 22 Nov 2023 – 00:00 (UTC)
- Sort of Contract
- Job Standing
- Is the job funded by means of the EU Analysis Framework Programme?
- Not funded by an EU programme
- Is the Job associated to employees place inside a Analysis Infrastructure?
Wage: £32,982 to £34,980 each year
Fastened Time period (- 30/09/2024)
Put up Sort: Full Time
Closing Date: 23.59 hours BST on Wednesday 22 November 2023
As a part of the British Coronary heart Basis mission focussed on omics approaches to establish regulators of vascular remodelling in pulmonary hypertension, we provide an thrilling place on the College of Well being and Medical Sciences, College of Surrey, to work inside the group of Prof Inga Prokopenko, PhD and inside the Part of Statistical MultiOmics in addition to inside the Individuals-Centred AI institute. This function will deal with large-scale multiomic information analyses accessible for the massive UK-based research for pulmonary hypertension with main deal with epigenome-wide affiliation research (EWAS) analyses and mixing of such data with proteomic information, scientific traits and different layers of knowledge.
Pulmonary arterial hypertension (PAH) is a uncommon situation characterised by pulmonary vascular remodelling resulting in untimely demise from proper coronary heart failure. We carried out a pilot research of blood DNA methylation evaluation of PAH sufferers from a UK PAH Cohort. We gained entry to accessible information from additional controls from two distinct research utilizing the identical Illumina IScan-EPIC 800k array chip, with analyses indicating baseline associations between methylation standing and PAH prognosis. One of many lead candidates is a CpG close to the CTSZ gene, encoding a lysosomal cysteine proteinase cathepsin Z expressed ubiquitously in most cancers cell strains and a number of tumours, which may work together with integrin-β3 activating FAK/Src signalling. How DNA methylation patterns alter over time in response to remedy and in different types of PH has but to be established.
The info from serially sampled PAH sufferers will enable analyses of the connection between dynamic adjustments in DNA methylation standing and scientific phenotypes as detailed above. We’ll additional broaden the DNA methylation analyses to different types of PH (e.g. secondary to lung illness, coronary heart failure or thromboembolism) utilizing 100 illness controls and 300 PH sufferers of combined aetiologies utilizing the established pipelines (The CPACOR pipeline – printed by Lehne et al. was used for the processing on genome construct GRCh37/hg19, high quality management (QC) and normalisation of the uncooked methylation information). Such an expanded EWAS evaluation would enable the willpower of the specificity of recognized adjustments to PAH and additional the definition of methylation patterns figuring out and co-occurring in different shows of PH.
We’re in search of candidates with experience in an space pertinent to the mission and expertise in superior statistics, machine studying, information integration, software program growth, sensor/wearable/cellular information, programming utilizing C++/Python, and/or biomedical informatics. The profitable candidate is predicted to have the ability to organise his/her work with minimal supervision and prioritise work to fulfill deadlines of the mission. On account of energetic collaborative interplay inside this mission, superior oral and writing English information are required.
What we will supply
Along with your wage, you’ll obtain pension contributions, a beneficiant annual go away entitlement, relocation help the place applicable, a lovely analysis setting, and entry to quite a lot of employees growth alternatives. Moreover, our profit packages embody childcare help and discounted membership to College sports activities amenities.
How one can apply
To use for this function, please submit your CV and a canopy letter addressing the main necessities of the submit.
If you want to debate your curiosity on this function, please contact Prof Inga Prokopenko straight by way of e mail [email protected]
The College of Surrey is dedicated to offering an inclusive setting that gives equal alternatives for all. We place nice worth on range and are in search of to extend the variety inside our group. Subsequently we notably encourage purposes from under-represented teams, comparable to folks from Black, Asian and minority ethnic teams and other people with disabilities.
Additional particulars: Job Description
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- UNIVERSITY OF SURREY
- United Kingdom
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