Research Assistant neuronal cell biologist: “Biomarkers of lysosomal dysfunction in Parkinson’s disease”

Full-time, Fastened-term for two years

Purposes are invited for a Analysis Assistant neuronal cell biologist to work on a mission to find novel biomarkers of lysosomal dysfunction in Parkinson’s illness. The mission, funded by the Michael J Fox Basis and in collaboration with EndLyz, a brand new firm throughout the Dementia Discovery Fund (DDF) portfolio, represents an thrilling alternative to undertake translation work on the interface between tutorial analysis and pharmaceutical goal and drug discovery in an distinctive setting. This work will develop novel biomarkers to raised perceive lysosomal dysfunction in Parkinson’s by working with induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s sufferers.

Duties will embody enterprise laboratory experiments; interpretation of knowledge; imaging evaluation; technology and research of iPSC-derived neurons and cell strains; preparation of knowledge for publication; research biomarker read-outs of endolysosomal dysfunction in mobile fashions of Parkinson’s; contribute to wider mission planning and decide probably the most acceptable methodologies to check hypotheses. You should have wonderful sensible expertise of working with induced pluripotent stem cell cultures and good information of mobile fashions of neurodegenerative illness. The power to innovate, trouble-shoot technical issues, be meticulous in sensible work and in document conserving is crucial.

Candidates should maintain, or be close to completion of, a BSc/MSc in a related space of analysis and have expertise in mobile neuroscience or molecular cell biology related to evaluation of neuronal phenotypes.

The put up is on the market for twenty-four months to begin on January 1st 2024. The put up shall be based mostly within the Kavli Institute for Nanoscience Discovery, South Parks Highway, Oxford, OX1 3PT

Casual enquiries could also be directed Professor Richard Wade-Martins ([email protected]).

Cut-off date for functions is noon on Thursday 11 April 2024.

Interviews are prone to be held on the week starting 22 April 2024.

Purposes are significantly welcome from girls, black and minority ethnic candidates who’re under-represented in tutorial posts in Oxford.

Whereas this can be a full-time function, we welcome functions from people who want to be thought-about for part-time working or different versatile working preparations.

We, as a Division and Neighborhood, shall be thoughtful and welcoming of all folks, no matter race, ethnicity, faith, incapacity, sexual orientation and gender id. We acknowledge societal inequalities and the way these affect us, and people round us, personally and professionally. – DPAG Assertion of Inclusion