Research Associate

Imperial College London

Job description
Job abstract

This can be a submit for one among two gifted, pro-active and enthusiastic Analysis Affiliate to hitch our program of analysis funded by the British Coronary heart Basis. The profitable candidates will probably be becoming a member of a well-developed venture that furthers our understanding of position of COX-2 within the cardiovascular system. They may also discover and develop new analysis avenues within the space throughout the workforce.

The analysis addresses the mechanism(s) by which cyclooxygenase-2 (COX-2) protects the cardiovascular system. COX-2 is an enzyme positioned inside discreet areas together with the kidney, mind, intestine, lungs, thymus and a few areas of vascular endothelium. In a number of of those areas COX-2 exercise protects the cardiovascular system from hypertensions, atherosclerosis, and thrombosis. We all know this as a result of frequent ache drugs, which work by blocking COX-2, elevate a person’s private threat of getting a coronary heart assault or stroke by as a lot as 30%. This system of labor includes a multidisciplinary method together with tissue from animal fashions, human samples and cell primarily based fashions, single and multi-analyte immune primarily based assays and gene expression evaluation utilizing qPCR and transcriptomic approaches.

Two positions can be found –  MED04248 & MED04257 . Each positions will use in vitro fashions and analytical approaches.  One may also concentrate on scientific pattern evaluation and the opposite on animal/tissue approaches. Candidates are inspired to use for one or each positions relying on their expertise and pursuits.

Duties and tasks

You be part of a well-developed venture as half of a bigger analysis group. As a part of this venture, you’ll carry out key experiments and work with our collaborators to finish ongoing experiments to progress the analysis query and contribute to publications. Additionally, you will carry out extra exploratory experiments to make novel observations – utilizing your personal initiative to design and perform experiments to inside our program of analysis. You may be anticipated to handle and preserve an up-to-date lab information archive and to optimise experiments to have the ability to generate sturdy and reproducible information.  

You’ll work intently with members of the group and be anticipated to help and advise different members of the workforce as required. As a part of our workforce, you can be anticipated to attend conferences/conferences to current your work and obtain suggestions from others. You may be liable for complying with all elements of governance (human tissue, animals, well being and security and so forth) regarding your work and help others who your work with and/or supervise/prepare in governance compliance. The position will probably be primarily based full-time on-site and adaptability to often work out-of-hours (evenings and weekends) is required.

Important necessities

Candidates must be extremely motivated, proactive, and impressive. As well as, candidates should maintain or be about to acquire a PhD in Pharmacology, or intently associated, self-discipline, or equal analysis, industrial or industrial expertise. Candidates who haven’t but been formally awarded their PhD will probably be appointed as Analysis Assistant. As well as the next expertise is required:

  • A powerful background in pharmacological approaches and cardiovascular biology
  • Expertise with cell tradition of human vascular or inflammatory cells
  • Expertise with analytical approaches together with immunoassay (ELISA) and qPCR
  • It’s fascinating however not important for candidates even have expertise with working with scientific samples, tissue dissection, animal dealing with, rodent vascular surgical procedure and cardiovascular bioassays e.g. platelet aggregometry or organ baths/myography in addition to different basic laboratory expertise e.g. imaging and move cytometry.

Additional data

This place is full-time and stuck time period (till thirtieth June 2024 primarily based at South Kensington Campus.

Candidates who haven’t but been formally awarded their PhD will probably be appointed as a Analysis Assistant throughout the wage vary £40,694 – £43,888 each year.

Candidates want to finish a web based software with a canopy letter stating why they wish to work with the workforce, what they will carry to the position and highlighting how they meet the important and fascinating expertise of the position.

Must you require any additional particulars concerning the position, please contact Dr Nicholas Kirkby, [email protected] and Professor Jane A. Mitchell, [email protected]


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