Research Associate

Job id: 086465. Wage: £43,205 – £44,347 each year, together with London Weighting Allowance.

Posted: 20 March 2024. Cut-off date: 01 Might 2024.

Enterprise unit: College of Life Sciences & Drugs. Division: Gene Remedy and Regenerative Drugs.

Contact particulars:Francesca Spagnoli. [email protected]

Location: Man’s Campus. Class: Analysis.

Job Description

We’ve postdoctoral Analysis Affiliate positions out there within the Spagnoli lab. within the Centre for Gene Remedy and Regenerative Drugs at King’s School London. Our group makes use of interdisciplinary approaches for finding out pancreas improvement and islet cell engineering from stem cells. The candidates might be a part of a T1D Grand Problem-funded analysis programme aiming at harnessing the islet microenvironment in all its complexity for stem cell remedy of diabetes.

That is an thrilling interdisciplinary analysis programme that may require experience in stem cell tradition, human tissue, bioengineering, computational analytical strategies and islet transplantation. Candidates ought to have a latest Ph.D. diploma or have submitted his/her Ph.D. thesis. We want to appoint extremely motivated people: one PDRA with background in improvement and stem cell biology and one PDRA with background in stem cell biologyand animal mannequin transplantation.

The Spagnoli lab. is coordinating the multi-partner, interdisciplinary consortium and might be primarily liable for creating revolutionary approaches to carefully mimic key options of the native in vivo islet microenvironment utilizing stem cells. The candidates might be main these efforts and assist in creating this formidable analysis program.

The Spagnoli lab. is a extremely dynamic, inclusive group, doing thrilling science and member of the excellent Centre for Gene Remedy & Regenerative Drugs at King’s School London, UK. This can be a world-class analysis surroundings with all services important for this formidable analysis programme.

The posts might be provided on an a fixed-term contract for 36 months.

This position is a Lab based mostly position with candidates to be based mostly 1005 on campus.

This can be a full-time publish – 100 % full time equal.

Key Obligations

• Undertake authentic biomedical analysis as an integral member of a gaggle engaged on pancreatic improvement and stem cells, utilizing iPSC, human mounted tissues and animal mannequin (mouse)
• Develop novel bioengineering approaches to practical examine cell-cell interactions and area of interest components in vivo within the stem cell-based human fashions of pancreatic improvement
• Use most up-to-date computational evaluation to analyse single-cell RNASeq dataset and determine cell-cell interactions and ligand-receptor pairs
• Concerned in transplantation experiments of SC-derived islets in diabetic mouse fashions and consequence evaluation
• Help, supervise and practice different members of the group, together with college students and different analysis workers of their software in associated lab initiatives
• Handle the progress and set targets for achievement of challenge goals in collaboration with group chief together with the execution of literature evaluations, knowledge assortment and evaluation, and report
• Put together studies on outcomes for verbal and multimedia shows at common lab conferences, departmental seminars, nationwide and worldwide conferences
• Put together manuscripts for publication in peer assessment journals or ebook chapters
• Facilitate collaboration and networking, which engages and helps the actions of this analysis
• Talk and collaborate with different members of the group and of the multi-partner consortium
• Keep up-to-date, correct and complete laboratory notes

The above checklist of duties might not be exhaustive, and the publish holder might be required to undertake such duties and duties as might fairly be anticipated inside the scope and grading of the publish.

Expertise, information, and expertise

Important standards

PhD (awarded or close to completion) in Organic Sciences or associated self-discipline

Experience in cell tradition (human ES and/or iPS cells)

Data of developmental and cell biology

Normal web-lab expertise together with molecular biology

Experience in imaging acquisition and evaluation (confocal, multiphoton)

Primary Expertise in single-cell RNASeq evaluation

Monitor file of publishing within the analysis space

Glorious communication (oral and written) expertise

Self-motivated, with the flexibility to work underneath strain & to satisfy deadlines

Expertise in working collaboratively

Glorious file retaining, working and designing experiments independently

In a position to supervise, work and combine with others within the laboratory

Fascinating standards

Expertise in pancreas improvement and islet biology

Robust computing expertise: programming expertise, competence in using imaging evaluation software program (Picture J, QPath, Imaris, MATLAB, machine studying)

Experience in bioengineering, biomaterials

* Please word that this can be a PhD degree position however candidates who’ve submitted their thesis and are awaiting award of their PhDs might be thought-about. In these circumstances the appointment might be made at Grade 5, backbone level 30 with the title of Analysis Assistant. Upon affirmation of the award of the PhD, the job title will turn into Analysis Affiliate and the wage will enhance to Grade 6.

We ask all candidates to submit a duplicate of their CV, together with aChecklist of publications and the contact info of two or extrareferences, and a supporting assertion, detailingof earlier and future analysis pursuits and the way they meet the important standards listed within the advert. If we obtain a robust area of candidates, we might use the fascinating standards to decide on our last shortlist, so please embrace your proof towards these the place attainable.