Research Associate

Job id: 086465. Wage: £43,205 – £44,347 each year, together with London Weighting Allowance.

Posted: 20 March 2024. Cut-off date: 01 Could 2024.

Enterprise unit: School of Life Sciences & Drugs. Division: Gene Remedy and Regenerative Drugs.

Contact particulars:Francesca Spagnoli. [email protected]

Location: Man’s Campus. Class: Analysis.

Job Description

We have now postdoctoral Analysis Affiliate positions obtainable within the Spagnoli lab. within the Centre for Gene Remedy and Regenerative Drugs at King’s Faculty London. Our workforce makes use of interdisciplinary approaches for learning pancreas improvement and islet cell engineering from stem cells. The candidates might be a part of a T1D Grand Problem-funded analysis programme aiming at harnessing the islet microenvironment in all its complexity for stem cell remedy of diabetes.

That is an thrilling interdisciplinary analysis programme that may require experience in stem cell tradition, human tissue, bioengineering, computational analytical strategies and islet transplantation. Candidates ought to have a latest Ph.D. diploma or have submitted his/her Ph.D. thesis. We want to appoint extremely motivated people: one PDRA with background in improvement and stem cell biology and one PDRA with background in stem cell biologyand animal mannequin transplantation.

The Spagnoli lab. is coordinating the multi-partner, interdisciplinary consortium and might be primarily answerable for growing revolutionary approaches to intently mimic key options of the native in vivo islet microenvironment utilizing stem cells. The candidates might be main these efforts and assist in growing this formidable analysis program.

The Spagnoli lab. is a extremely dynamic, inclusive workforce, doing thrilling science and member of the excellent Centre for Gene Remedy & Regenerative Drugs at King’s Faculty London, UK. This can be a world-class analysis atmosphere with all services important for this formidable analysis programme.

The posts might be supplied on an a fixed-term contract for 36 months.

This position is a Lab primarily based position with candidates to be primarily based 1005 on campus.

This can be a full-time publish – 100 % full time equal.

Key Duties

• Undertake authentic biomedical analysis as an integral member of a gaggle engaged on pancreatic improvement and stem cells, utilizing iPSC, human mounted tissues and animal mannequin (mouse)
• Develop novel bioengineering approaches to useful examine cell-cell interactions and area of interest elements in vivo within the stem cell-based human fashions of pancreatic improvement
• Use most up-to-date computational evaluation to analyse single-cell RNASeq dataset and determine cell-cell interactions and ligand-receptor pairs
• Concerned in transplantation experiments of SC-derived islets in diabetic mouse fashions and final result evaluation
• Help, supervise and prepare different members of the group, together with college students and different analysis employees of their software in associated lab tasks
• Handle the progress and set objectives for achievement of challenge goals in collaboration with workforce chief together with the execution of literature opinions, knowledge assortment and evaluation, and report
• Put together experiences on outcomes for verbal and multimedia shows at common lab conferences, departmental seminars, nationwide and worldwide conferences
• Put together manuscripts for publication in peer assessment journals or e book chapters
• Facilitate collaboration and networking, which engages and helps the actions of this analysis
• Talk and collaborate with different members of the workforce and of the multi-partner consortium
• Keep up-to-date, correct and complete laboratory notes

The above record of tasks might not be exhaustive, and the publish holder might be required to undertake such duties and tasks as might fairly be anticipated inside the scope and grading of the publish.

Expertise, information, and expertise

Important standards

PhD (awarded or close to completion) in Organic Sciences or associated self-discipline

Experience in cell tradition (human ES and/or iPS cells)

Information of developmental and cell biology

Common web-lab expertise together with molecular biology

Experience in imaging acquisition and evaluation (confocal, multiphoton)

Fundamental Expertise in single-cell RNASeq evaluation

Observe document of publishing within the analysis space

Glorious communication (oral and written) expertise

Self-motivated, with the flexibility to work beneath strain & to fulfill deadlines

Expertise in working collaboratively

Glorious document retaining, working and designing experiments independently

In a position to supervise, work and combine with others within the laboratory

Fascinating standards

Expertise in pancreas improvement and islet biology

Sturdy computing expertise: programming expertise, competence in using imaging evaluation software program (Picture J, QPath, Imaris, MATLAB, machine studying)

Experience in bioengineering, biomaterials

* Please word that this can be a PhD stage position however candidates who’ve submitted their thesis and are awaiting award of their PhDs might be thought-about. In these circumstances the appointment might be made at Grade 5, backbone level 30 with the title of Analysis Assistant. Upon affirmation of the award of the PhD, the job title will turn into Analysis Affiliate and the wage will enhance to Grade 6.

We ask all candidates to submit a duplicate of their CV, together with aRecord of publications and the contact data of two or extrareferences, and a supporting assertion, detailingof earlier and future analysis pursuits and the way they meet the important standards listed within the advert. If we obtain a robust area of candidates, we might use the fascinating standards to decide on our ultimate shortlist, so please embody your proof in opposition to these the place potential.