University of Bath
Job title:
Research Associate (AP12509)
Company
University of Bath
Job description
We are seeking a full-time time highly motivated post-doctoral research associate to join the NanoImmunology and Molecular Pharmaceutics group, led by Dr Iris Da Luz Batalha, in the Department of Life Sciences at the University of Bath.Our group is currently focusing on the development of nanomedicine-based approaches for the modulation of the immune system. This modulation can be either an activation of the immune system against diseases such as cancer and infections, or an inhibition of the immune system in diseases with exacerbated immune responses, including autoimmune disorders and sepsis.Specifically, the successful candidate will be working on the identification and validation of peptide ligands that target antigen-presenting cells (APCs) through their unique metabolic profile using MHC class I-related protein 1 (MR1) presentation, a term that our group coined Dynamic TargetingYour role within this project will be as a principal researcher responsible for project deliverables, including:
- Protein Expression and Purification: Independently design and implement strategies for recombinant protein production in bacterial and mammalian systems, troubleshooting challenges and optimising yields.
- Phage Display: Plan and complete phage display experiments, from library selection to hit validation, contributing to the discovery of novel binding partners.
- Cell Line Engineering: Direct the development of engineered cell lines, coordinating all aspects from construct design and transfection to clone selection and characterisation.
- Characterisation of molecular interactions: Utilise a range of biophysical and biochemical methods, including enzyme-linked immunosorbent assay (ELISA), Fluorescence-activated Cell Sorting (FACS), and confocal microscopy, to quantify and analyse ligand-receptor binding.
Our ideal candidate will have:
- A PhD or equivalent in a relevant subject
- Postdoctoral experience in a relevant research field
- Established area of expertise in research
- Experience successfully supervising other staff and students
- Hands-on experience in protein expression and purification, CRISPR/Cas9 genome-editing, lentiviral transduction, FACS, and confocal microscopy
- Excellent communication skills, both verbal and written
- Proven ability to excel at collaboration and teamwork, fostering productive relationships across multiple working groups and institutions
In addition, the successful candidate will be assisting with lab managing tasks, including (i) equipment maintenance; (ii) ordering, stocking, and keeping an up-to-date inventory of lab supplies; (iii) maintaining a clean and organised lab environment and ensuring compliance with health and safety regulations; and (iv) training students and junior researchers.As a member of Research Staff at the University of Bath, we will encourage you to take up a minimum of 10 days professional development pro rata per year.This is a fixed-term position for 9 months.For informal discussions regarding this vacancy please contact Dr Iris Luz BatalhaWhat we can offer you:We consider ourselves to be a university where difference is celebrated, respected and encouraged. We have an excellent international reputation with staff from over 60 different nations and have made a positive commitment towards gender equality and intersectionality receiving a . We truly believe that diversity of experience, perspectives, and backgrounds will lead to a better environment for our employees and students, so we encourage applications from all genders, backgrounds, and communities, particularly from under-represented groups, and value the positive impact that will have on the university. We are committed to maintaining a safe and secure environment for our students, staff, and community by reinforcing our commitment.We are very proud to be an and are an accredited ; committed to .
- Free counselling services through Health Assured
- Cycle to work scheme
- Electric vehicle salary sacrifice scheme
- Staff discount at Team Bath gym
- Staff discounts on postgraduate tuition fees
- Staff discount on language courses
- Generous employer contributory pension schemes
- Generous annual leave allowance with an additional 5 discretionary days so that you can enjoy a positive work life balance
- A wide range of personal and professional development opportunities including Apprenticeships, LinkedIn Learning and more
- Free entry to the Holburne Museum in Bath
- Local discounts and more
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- An excellent reward package that recognises the talents of our diverse workforce
and to help with the cost of some immigration expensesWe are committed to continually expanding our benefits to better support you and enhance your experience with us. .what makes the University of Bath a great place to work. Follow us and on X for more information.Further details:We are constantly seeking to reduce the unconscious bias that enters any assessment process, with the goal of creating an inclusive and equal assessment process. To support this, personal details such as your name, may be removed from application forms at the initial shortlisting stage.
Expected salary
£38249 – 45413 per year
Location
Bath
Job date
Sun, 09 Mar 2025 00:12:14 GMT
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