King's College London
Job id: 069205. Salary: £41,386 – £48,414 per annum, including London Weighting Allowance.
Posted: 16 June 2023. Closing date: 30 July 2023.
Business unit: IoPPN. Department: Basic & Clinical Neuroscience.
Contact details:Christopher Miller. [email protected]
Location: Guy’s Campus. Category: Research.
Applications are invited for a postdoctoral research associate to be based in the Department of Basic and Clinical Neuroscience and the Randall Centre for Cell and Molecular Biophysics at King’s College London. The post is funded by the UK Medical Research Council for 3 years and will investigate the role of defective endoplasmic reticulum (ER)-mitochondria signaling in dementia and amyotrophic lateral sclerosis (ALS). ER-mitochondria signaling and its role in dementia/ALS are highly topical areas of research and the grant holders have made major contributions to these fields. The successful applicant will join a multi-disciplinary group that seeks to understand the mechanisms by which ER-mitochondria signaling is perturbed in dementia/ALS and how correcting damaged ER-mitochondria signaling might be therapeutic for these major diseases. The post will focus on how phosphorylation affects ER-mitochondria tethering and signaling, and how disruption to ER-mitochondria signaling affects key neuronal functions in dementia/ALS. Experience in cell and molecular biology approaches including advanced light microscopy, experimental manipulation of neurons and working with transgenic mouse models would be advantageous. Knowledge of defective signaling processes in dementia and related disorders will also be useful. The successful applicant will join an established research group and will have access to state-of-the-art facilities in both King’s College and the King’s College Dementia Research Institute. For further information on our work see https://kclpure.kcl.ac.uk/en/persons/christopher-miller
This post will be offered on an a fixed-term contract until 31-Dec-2026
This is a full-time post – 100% full time equivalent
- To use Mass Spectrometry (MS) in collaboration with MS units to identify phosphorylation sites in ER-mitochondria tethering proteins.
- To use cell, molecular and advanced microscopy approaches to understand the roles of this phosphorylation in binding of tethering proteins and ER-mitochondria signaling functions.
- To generate antibodies to defined phosphorylation sites in tethering proteins and to use these to probe the roles of phosphorylation in dementia and ALS.
- To determine how disruption of ER-mitochondria tethering affects key neuronal functions linked to dementia and ALS using transgenic mouse and cell biology approaches.
- To conduct literature reviews and contribute to publications arising from this project.
- Attend and as appropriate, present research findings and papers at internal and external academic meetings and external professional conferences, and to contribute to the internal and external visibility of the departments and group.
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.
Shortlisted applicants will be invited to give a Powerpoint presentation of some of their recent research as part of the interview process.
We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.
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