Research Associate in Bioinformatics

Imperial College London


Job description
Job summary

We are seeking to recruit a Research Associate in the field of bioinformatics to work in a world-leading research group at the intersection of molecular biology and insect vector control.

You will join the laboratory of Professor Andrea Crisanti based at the South Kensington Campus. Our research is based on cutting-edge molecular biology and genetics to understand and ultimately control the mosquito vectors of malaria. Our current focus is on the development of vector control strategies that are mainly based on gene drive systems. The projects typically involve generation of transgenic mosquito strains, genetic and phenotypic assays, mathematical modelling and multigenerational experiments to assess the effect and efficiency of the technology on caged populations.

Duties and responsibilities

As the dedicated bioinformatician for the group you will take initiatives in the planning of research and conduct data analysis. You will be required to maintain accurate and complete records of all findings and to provide bioinformatics assistance to Group members with Next-generation sequencing (NGS) data (e.g. RNA-Seq, scRNA-Seq, amplicon sequencing) from experiments with laboratory-reared mosquitoes and population genetics (e.g. individual genome re-sequencing) data.

Based on input from researchers of the group, you will be able to identify and execute suitable workflows and techniques to plan experiments for data collection, modelling and analyses. A key element of the role will be in helping to plan experiments in collaboration with wet lab researchers in order to ensure there is sufficient scientific power to answer the question at hand. A fundamental skill the applicant must possess is the ability to communicate their workflow and a breakdown of their analysis to a wide range of biologists that may not have a large amount of bioinformatics experience. You may also be required to collaborate with other allied scientists within Imperial College and elsewhere in London and abroad as appropriate.

Essential requirements

You should hold, or be near completion of, a PhD in an appropriate biological science or computational discipline with a strong focus on bioinformatics, computational biology and genomics. The post requires a good knowledge combination of computational methods, molecular biology, genomics, transcriptomics. Post-doctoral experience of working in a similar environment would be desirable, though not essential.

Experience in building pipelines and using tools for NGS data analysis is essential. The successful candidate must have strong programming skills (preferably R and/or Python), high working proficiency in a Unix/Linux environment and experience with high-performance computing (HPC). Experience in analysis of data produced by RNA-seq and WGS methods is also required, whereas experience in analysis of data produced by scRNA-seq, CHIP-seq, Cut&Tag, ATAC-Seq methods in not essential, though advantageous.

Previous work experience in the field of insect biology is preferred, but not essential.

You must have excellent verbal and written communication skills. You must also be able to develop and apply new concepts and have a creative approach to problem-solving. The ideal candidate will have the passion and drive to tackle and overcome scientific problems.

Further information

This is a full time, fixed-term position until 31 January 2025, extendable subject to funding renewal.

You will be based at South Kensington Campus and a hybrid working pattern is available and can be agreed with the line manager. The starting salary will be in the range defined, depending on experience. Appointments will usually be made at the bottom of the scale.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 – £41,388 per annum.

Should you require any further details on the role please contact: Professor Andrea Crisanti] – [via [email protected] ] or Dr Federica Bernardini ([email protected] )

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA),which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

 The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

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