Research Associate in Bioinformatics and Machine Learning

Job title:

Research Associate in Bioinformatics and Machine Learning

Company

Cardiff University

Job description

School / DirectorateSchool of MedicineAdvertResearch Associate in Bioinformatics and Machine Learning
Division of Psychological Medicine and Clinical Neurosciences
School of Medicine
College of Biomedical and Life SciencesWe have an exciting opportunity to appoint an enthusiastic and experienced Bioinformatician to join Professor Valentina Escott-Price’s research group within the UK Dementia Research Institute at Cardiff University. The post holder will play a leading role in the analysis of large and complex genetic datasets with a range of Machine Learning approaches, whilst leading a broad range of investigative and analytical activities to maximally exploit gene x gene and gene x environment interactions in clinical and genetic data and linking them to an individual risk score with the aim to reveal novel therapeutic targets in dementia. They will help refine inclusion criteria for future clinical trials and ultimately translate into guidance for personalized healthcare decisions. The successful applicant will have the opportunity to take part in cutting-edge research investigating the complex architecture of dementia and related subphenotypes in human data.In this role, you will work independently and as part of a multi-disciplinary team, to perform self-directed analyses using in house and publicly available datasets for high impact, peer-reviewed publications. Applicants should be knowledgeable and enthusiastic with the ability to multi-task and communicate effectively. Core tasks will include data analysis and management of genetic, genomic and related phenotypic data from dementia case-control and cohort samples, publicly available and in-house generated genomic human data. Collaborative working is a key component of this role meaning that communication skills will be vital, in order to cultivate international collaborations from a number of academic institutions.We’d like to hear from you if you have a background in machine learning and biostatistics with proven experience of extensive large-scale data analyses and manipulation, including analysis of genome-wide association studies and genetic interactions. Expert knowledge of data manipulation in a UNIX/Linux environment and proficiency in high level programming languages such as Python and R Statistics is essential. Knowledge of techniques used in genetics and epidemiology, as well as experience in using software used for the analysis of genomic data such as PLINK, LDScore, is desirable.For informal enquiries please contact Professor Valentina Escott-Price ( )This post is full-time (35 hours per week), available from 01.11.2024 and fixed term until 30.09.2025, based at the Hadyn Ellis Building, Cathays campus.Salary: £40,247 – £45,163 per annum (Grade 6). Appointments to roles at Cardiff University are usually made at bottom of scale unless in exceptional circumstances.The majority of roles at Cardiff University are currently operating under “blended working” arrangements, with staff having the flexibility to work partly from home and partly from the University campus depending on specific business requirements. Discussions around these arrangements can take place after the successful candidate has been appointed.Cardiff University offers many excellent benefits, including 45 days annual leave (incl bank holidays), local pension scheme, a cycle to work scheme and other travel initiatives, annual increments within the pay scale, and more. It is an exciting and vibrant place to work, with many different challenges and is a proud Living Wage supporter.Date advert posted: Thursday, 14 November 2024Closing date: Sunday, 1 December 2024Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds. We therefore welcome applicants from all sections of the community regardless of sex, ethnicity, disability, sexual orientation, trans identity, relationship status, religion or belief, caring responsibilities, or age. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.Cardiff University is a signatory to the San Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions we will evaluate applicants on the quality of their research, not publication metrics or the identity of the journal in which the research is published. More information is available at:Applications may be submitted in Welsh, and an application submitted in Welsh will not be treated less favourably than an application submitted in English.Post Reference Number19246BRJob DescriptionJob Purpose
To conduct research principally within biostatistics, Machine Learning and bioinformatics associated with Alzheimer’s disease and dementia genetics in larger population studies, and to contribute to the overall research performance of the School and University, carrying out research leading to the publishing of work in high-quality journals. To pursue excellence in research and to inspire others to do the same.Duties and ResponsibilitiesKey DutiesResearch

• To conduct research within biostatistics, Machine Learning and bioinformatics associated with Alzheimer’s disease and dementia genetics in large cohorts.
• To contribute to the overall research performance of the School and University by the production of measurable outputs including bidding for funding, publishing in national academic journals and conferences, and the recruitment and supervision of postgraduate research students.
• To develop research objectives and proposals for own or joint research including research funding proposals.
• To attend and or present at conferences/seminars at a local and national level as required.
• To undertake administrative tasks associated with the research project, including the planning and organisation of the project and the implementation of procedures required to ensure accurate and timely reporting.
• To prepare research ethics and research governance applications as appropriate.
• To review and synthesise existing research literature within the field.
• To participate in School research activities.
• To build and create networks both internally and externally to the university, to influence decisions, explore future research requirements, and share research ideas for the benefit of research projects.

Other

• To engage effectively with industrial, commercial and public sector organisations, professional institutions, other academic institutions etc., regionally and nationally to raise awareness of the School’s profile, to cultivate strategically valuable alliances, and to pursue opportunities for collaboration across a range of activities. These activities are expected to contribute to the School and the enhancement of its regional and national profile.
• To undergo personal and professional development that is appropriate to, and which will enhance performance.
• To participate in School administration and activities to promote the School and its work to the wider University and the outside world.
• Any other duties not included above, but consistent with the role.

Salary Range Max.45,163GradeGrade 6Salary Range Min.40,247Job CategoryAcademic – Research, Health, Medical & DentalAdditional InformationIMPORTANT: Evidencing Criteria
Candidates should evidence that they meet ALL of the essential criteria as well as, where relevant, the desirable criteria.As part of the application process, you will be asked to provide this evidence via a supporting statement. Please ensure when submitting this document / attaching it to you application profile you name it with the vacancy reference number, in this instance, 19246BRThe project is embedded within the UK Dementia Research Institute at Cardiff University. The post holder will work with Prof. Valentina Escott Price, and will attend and contribute to meetings and seminars. There will be an opportunity to interface with a variety of international cohorts for data analysis, and the opportunity to publish in high quality journalsHow we will support you in performing in this role
There are some things that you must have before you can start this role (see ‘Essential Criteria’), but other things can be developed either through training, or just by general on-the-job experience. We want to support and develop you once you have started in the role using a combination of the following to get the best out of you:1. Regular one-to-ones with your manager
2. An experienced and supportive team around you
3. Supporting you through job-relevant training and development that you may require
4. A mentoring schemeCareer PathwayResearchPerson SpecificationEssential CriteriaQualifications and Education * Postgraduate degree at PhD level (or nearing completion / submission) in a related subject area or relevant industrial experience.
Knowledge, Skills and Experience * An established expertise and proven portfolio of research and/or relevant industrial experience within the following research fields:– Biostatistics/Bioinformatics in complex genetic analyses
– Genetics of complex diseases
– High Performance Computing
– Big data manipulation and analyses
– Machine Learning * Knowledge of current status of research in biostatistics, bioinformatics, machine learning, data simulation techniques, genetic interaction analyses.

• Proven ability to publish in national and international journals.
• Knowledge and understanding of competitive research funding to be able to develop applications to funding bodies.

Communication and Team Working * Proven ability in effective and persuasive communication.

• Ability to supervise the work of others to focus team efforts and motivate individuals.

Other * Proven ability to demonstrate creativity, innovation and team-working within work

• Proven ability to work without close supervision.

Desirable Criteria * Undergraduate background/modules in either/or Psychology, Neuroscience, Computer Science or Mathematics.

• Knowledge of techniques used in genetics and epidemiology, as well as experience in using software used for the analysis of genomic data such as Plink, GCTA, LDpred, LDScore, MAGMA, and techniques used for Federated Learning.
• Proven ability to adapt to the changing requirements of the Higher Education community.
• Evidence of ability to participate in and develop both internal and external networks and utilise them to enhance the research activities of the School.
• Ability to undertake academic related administration.

Expected salary

£40247 – 45163 per year

Location

United Kingdom

Job date

Wed, 06 Nov 2024 07:09:07 GMT

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