Research Associate in Molecular Oncology

Job title:

Research Associate in Molecular Oncology

Company

University of Bristol

Job description

The roleWe are seeking a highly motivated and enthusiastic Postdoctoral Research Associate for a Little Princess Trust/Children’s Cancer and Leukaemia Group funded “New Ideas” research project entitled “Using splice-switching oligonucleotides for cancer therapeutics”. The project builds on our recently published work demonstrating the spliceosomal vulnerability of neuroblastoma [Bojko etal, Cancer Letters 2024, ]. We propose that altering specific mRNA splicing events may selectively kill cancer cells, and we will assess targeted antisense oligonucleotides for this purpose. The post will be for up to 12 months (full-time).What will you be doing?This project will require a strong understanding of gene regulation, in particular regulation by post-transcriptional mRNA splicing. You will be expected to show strong initiative and be responsible for the planning, execution and analysis of the project’s experiments. In addition to molecular/biochemical/cell biology techniques, the project may require expertise in bioinformatic analyses.You should apply if

• You hold a relevant PhD (or working towards one).
• You need to possess high-level molecular/biochemical/cell biology practical skills, including ChIP, co-immunoprecipitation, qPCR, alternative splicing analysis, western-blotting, tissue-culture, confocal microscopy, immunocytochemistry, flow cytometry.
• You should also have practical experience of bioinformatics for proteomics and transcriptomics.

Additional informationFor informal enquiries please contact Karim Malik, +44 (0)117 4550106,Contract type: Open-ended (Fixed funding for 12 months)This advert will close at 23:59 UK time on Tuesday 22nd April 2025Our strategy and missionWe recently launched our to 2030 tying together our mission, vision and values.The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive and reach their full potential. We want to attract, develop, and retain individuals with different experiences, backgrounds and perspectives – particularly people of colour, LGBT+ and disabled people – because diversity of people and ideas remains integral to our excellence as a global civic institution.£38,249 to £44,128 per annum, Grade: I

Expected salary

£38249 – 44128 per year

Location

Bristol Area

Job date

Fri, 04 Apr 2025 22:36:24 GMT

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