Research Associate – INTERNAL ONLY

King's College London

Job id: 069085. Salary: Grade 6: £41,386 per annum, including London Weighting Allowance.

Posted: 15 June 2023. Closing date: 19 June 2023.

Business unit: Faculty of Life Sciences & Medicine. Department: Peter Gorer Department of Immunobiology.

Contact details:Stephen Till. [email protected]

Location: Guy’s Campus. Category: Research.

THIS VACANCY IS OPEN TO INTERNAL APPLICANTS ONLY

Job description

We are seeking to appoint a Research Associate for an initial 12 months with the likelihood of further extension for at least one year subject to confirmation of funding.  The post holder will undertake basic scientific research investigating cellular and molecular mechanisms principally relating to properties of mast cell and B cells in type 2 inflammation, using in in vitro experimental models and cells isolated from peripheral blood and tissue.    

The post holder will be responsible for processing of surgical nasal polyp, involving tissue digestion, isolation of immune cells subsets, multi-colour flow cytometry, cell sorting, cell culture and single cell transcriptomics.  

The appointee will also be required to provide laboratory supervision for undergraduate and masters students undertaking projects in the lab. They must have the ability to work effectively with colleagues, as well as being an excellent team-player. We require accurate entry of laboratory data into databases. Experience in working with human B cells and mast cells would be an advantage. They will be expected to contribute to other areas of research of the group as appropriate and participate in research meetings and internal seminars.   

  • To receive on-going support and development.
  • To take responsibility for personal professional development and make full use of the training facilities through KCL Staff Training and Development Unit.
  • To be aware of the risks in the work environment and their potential impact on own work and that of others.
  • To work in accordance with Kings and GSTT Hospital policies.
  • To be aware of and work within the guidelines for biomedical research set out in the Declaration of Helsinki (1989).
  • To carry out his/her responsibilities with regard to KCL Equal Opportunities Policy.
  • To be aware of the responsibilities placed upon them under the Health and Safety at Work Act 1974, to ensure that the agreed safety procedures are carried out to maintain a safe working environment for patients, visitors and employees.
  • To be compliant with all measures known to be effective in reducing healthcare-associated infections.  Employees must be familiar with Infection Control Policies, including those that apply to their duties, such as Hand Decontamination Policy, Personal Protective Equipment Policy, safe procedures for using aseptic techniques and safe disposal of sharps.

This post will be offered on an  a fixed-term contract for 12 months 

This is a full-time post

Key responsibilities

  • Basic cellular and molecular laboratory research on immune cells, particularly mast cells and B cells, both primary and cell lines  
  • Contribution to other areas of research of the group as appropriate  
  • Laboratory supervision of undergraduate and masters students where appropriate  
  • Data analysis and assistance with preparation of manuscripts for publication 
  • Participation in research meetings and internal seminars  

Skills, knowledge, and experience

The appointee must have a PhD and experience of working with freshly isolated mast cells and B cells from nasal polyp specimens, and also LAD2 mast cell lines, including cell culture, RT-PCR, flow cytometry, cell sorting and single cell transcriptomics.

Essential criteria  

1.      PhD in relevant subject 

2.      An excellent standard of written and spoken English  

3.      Experience of isolating immune cell populations from nasal polyp tissue 

4.      Experience of working with human mast cells in vitro 

5.      Experience in molecular biology (RNA extraction, RT-PCR and single cell transcriptomics) 

6.      Extensive knowledge of immunology concepts 

7.      Able to communicate effectively and work as part of a team 

Desirable criteria

1.      Experience of supervising undergraduate students undertaking laboratory projects 

Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

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