Research Associate (phosphoinositide signalling in colorectal cancer metastasis)

Job title:

Research Associate (phosphoinositide signalling in colorectal cancer metastasis)

Company

University of Glasgow

Job description

Job PurposeApplications are called for a postdoctoral research associate to work with the laboratories of Professor David Bryant and Professor Owen Sansom on the role of phosphoinositide signalling in colorectal cancer metastasis. The aim of this project is to investigate the mechanisms of metastasis emerging from a cutting-edge in vivo CRISPR screens of tumourigenesis and metastasis using transplantable organoid models of colorectal cancer. The successful candidate will also be expected to contribute as part of a multi-researcher team to the formulation and submission of research publications as well as help manage and direct this complex and challenging project as opportunities arise.Main Duties and Responsibilities1. Take a leading role in the planning and conduct of assigned research individually or jointly in accordance with the project deliverables and project/group/School/College research strategy. Research activities will be particularly focused on in vivo murine colorectal cancer studies and transplantable organoid culture and manipulation.2. Document research output including analysis and interpretation of all data, maintaining records and databases, drafting technical/progress reports and papers as appropriate.3. Establish and maintain your research profile and reputation and that of The University of Glasgow/School/ Research Group, including establishing and sustaining a track record of independent and joint publications of international quality in high profile/quality refereed journals, enhancing the research impact in terms of economic/societal benefit, and gathering indicators of esteem.4. Survey the research literature and environment, understand the research challenges associated with the project & subject area, & develop/implement a suitable research strategy.5. Presentation of work at international and national conferences, at internal and external seminars, colloquia and workshops to develop and enhance our research profile.6. Take a leading role in the identification of potential funding sources and to assist in the development of proposals to secure funding from internal and external bodies to support future research.7. Take a leading role in developing and maintaining collaborations with colleagues across the research group/School/College/University and wider community (e.g. Academic and Industrial Partners).8. Take a leading role in team/group meetings/seminars/workshops and School research group activities to enhance the wider knowledge, outputs and culture of the School/College.9. Take the lead in the organisation, supervision, mentoring and training of undergraduate and/or postgraduate students and less experienced members of the project team to ensure their effective development.10. Perform administrative tasks related to the activities of the research group and School, including Budgets/Expenditure.11. Keep up to date with current knowledge and recent advances in the field/discipline of cancer drug development.12. Engage in personal, professional and career development, to enhance both specialist and transferable skills in accordance with desired career trajectory.13. Undertake any other reasonable duties as required by the Head of School/Director of Research Institute.Contribute to the enhancement of the University’s international profile in line with the University’s Strategic Plan, World Changers Together.Knowledge, Qualifications, Skills and ExperienceKnowledge/QualificationsEssentialA1 Normally Scottish Credit and Qualification Framework level 12 (PhD) with at least 2 years’ post-doctoral experience in a similar or related role(s), or alternatively possess the equivalent in professional qualifications and experience.A2 A comprehensive and up-to-date knowledge of current issues and future directions within thewider subject area or subject specialism of cancer biology, cell biology, or molecular biology.SkillsEssentialC1 Skills working with model systems of cancer, such as genetically engineered mice or organoid models of cancer.C2 Proven ability to deliver quality outputs in a timely and efficient mannerC3 Ability to demonstrate a degree of independence as illustrated by identification of projectobjectives from assessment of the literature, design & analysis of experiments & drafting ofpapers.ExperienceEssentialE1 Sufficient depth of relevant research experience, normally including sufficient postdoctoralexperience in a related field, appropriate to an early career researcherE2 A track record of presentation and publication of research results in qualityjournals/conferencesE3 Experience of making a leading contribution in academic activitiesE4 Experience in undertaking independent researchE5 Commitment to open research, as appropriate to the discipline, through open data,open code, open educational resources and practices that support replication.E6 Proven commitment to supporting the career development of colleagues and to otherforms of collegiality appropriate to the career stageAdditional InformationApplications are invited to work with the labs of Professor David Bryant and Professor Owen Sansom on the role of phosphoinositide signalling in colorectal cancer metastasis. The Bryant Lab focuses on how cell and tissue polarity is controlled in the context of health and disease. We utilise 3-dimensional organoid culture coupled to state-of-the-art live-cell and high-throughput imaging, cell biology, biochemical and computational approaches to understand how tissue organisation is controlled. In this UKRI-funded collaboration with Owen Sansom’s lab, you will utilise organoids derived from mouse models of metastatic colorectal cancer to understand how phosphoinositides contribute to metastasis.The Bryant and Sansom labs are situated at The Cancer Research UK Scotland Institute as part of the University of Glasgow – one of Europe’s leading cancer research centres. It is core funded by Cancer Research UK and supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on mouse models, imaging and tissue organisation.The successful, highly motivated candidate is expected to follow-up on an innovative, cutting-edge in vivo CRISPR screening of transplantable organoid models of metastasis, as part of a team of researchers dedicated to this aim. In addition, the candidate is expected to lead more junior members of the laboratory in transplantable models of metastasis.https://www.crukscotlandinstitute.ac.uk/cruk-si-research/cruk-si-research-groups/dave-bryant-epithelial-polarity.htmlhttps://www.crukscotlandinstitute.ac.uk/cruk-si-research/cruk-si-research-groups/owen-sansom-colorectal-cancer-and-wnt-signalling.htmlInformal enquiries should be directed to Professor David Bryant (David.Bryant@glasgow.ac.uk).Terms and ConditionsSalary will be Grade 7, £40,247 – £45,163 per annum.This post is full time, and has funding for up to 2 years.​Closing Date: 17 March 2025 at 23:45

Expected salary

£40247 – 45163 per year

Location

Glasgow

Job date

Wed, 19 Feb 2025 00:31:12 GMT

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