Research Associate – Therapies for Renal Ciliopathies
Newcastle University
Salary: £33,966 to £36,024 per annumNewcastle University is a great place to work, with excellent . We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.Closing Date: 01 June 2024The RoleFollowing recent success in securing an EU HORIZON funded programme called Therapies for Renal Ciliopathies (TheRaCil, ), we are seeking a Research Associate to join our internationally renowned multi-disciplinary team in Newcastle.This position provides an opportunity for an outstanding Research Associate to develop their career within a team that brings together clinicians and academics in a vibrant translational research environment that works closely with patients and their families.
( ).You will be skilled in kidney research, translational research and have demonstrable experience with murine models of kidney development/disease, with a recent PhD in this area.We are looking for an exceptional individual able to lead on laboratory molecular techniques as well as perform in vivo experiments and interpret the findings.Mutations affecting the structure/function of primary cilia cause a heterogenous group of complex disorders that typically progress to end stage renal failure (ESFR) with dialysis and transplantation the only current treatment. Renal ciliopathies account for 10% of all patients with kidney failure and represent the main cause of ESRF during childhood. Although mutations in over 40 genes have been shown to underlie the renal ciliopathies, extensive genotype:phenotype heterogeneity means it is difficult to predict the severity of the disease and the rate of progression to ESRF. TheRaCil, aims to use models of renal ciliopathy diseases to drive translational research and bring treatments to the clinic within the next 5 years, see Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. Proc Natl Acad Sci USA. 2018 115(49):12489-12494. PMID: 30446612; Ramsbottom SA, Thelwall PE, Wood KM, Clowry GJ, Devlin LA, Silbermann F, Spiewak HL, Shril S, Molinari E, Hildebrandt F, Gunay-Aygun M, Saunier S, Cordell HJ, Sayer JA, Miles CG. Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome. Proc Natl Acad Sci USA. 2020 117(2):1113-1118. PMID: 31879347; and Garcia H, Serafin AS, Silbermann F, Porée E, Viau A, Mahaut C, Billot K, Birgy É, Garfa-Traore M, Roy S, Ceccarelli S, Mehraz M, Rodriguez PC, Deleglise B, Furio L, Jabot-Hanin F, Cagnard N, Del Nery E, Fila M, Sin-Monnot S, Antignac C, Lyonnet S, Krug P, Salomon R, Annereau JP, Benmerah A, Delous M, Briseño-Roa L, Saunier S. Agonists of prostaglandin E2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies. Proc Natl Acad Sci USA. 2022 119(18):e2115960119. PMID: 35482924.This post is fixed term for a period of 24 months in the first instance.Please note that if you are successful to this role, you will require medical clearance before you can commence in the role.For informal enquiries regarding the role, please contactFind out more about the Faculty of Medical Sciences here:Find out more about our Research Institutes here:As part of our commitment to career development for research colleagues, the University has developed 3 levels of . These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.Key Accountabilities
The PersonKnowledge, Skills and Experience
Desirable
Attributes and Behaviour
Desirable
Qualifications
Newcastle University is a global University where everyone is treated with dignity and respect. As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.We are committed to being a fully inclusive university which actively recruits, supports and retains colleagues from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all of our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from individuals who can complement our existing teams, we believe that success is built on having teams whose backgrounds and experiences reflect the diversity of our university and student population.At Newcastle University we hold a silver award in recognition of our good employment practices for the advancement of gender equality. We also hold a Bronze award in recognition of our work towards tackling race inequality in higher education REC. We are a employer and will offer an interview to disabled applicants who meet the essential criteria for the role as part of the offer and interview scheme.In addition, we are a member of the Euraxess initiative supporting researchers in Europe.Requisition ID: 27016
£33966 – 36024 per year
Newcastle
Fri, 03 May 2024 22:12:28 GMT
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