Research Fellow

Job title:

Research Fellow

Company

University of Edinburgh

Job description

Job Description:Grade UE07: £40,497 to £48,149 per annumMRC University Unit for Human GeneticsFull-time: 35 hours per weekFixed-term: for 18 monthsThe Opportunity:We have one Postdoctoral research opportunity working within the laboratory of Professor Javier F. Caceres at the MRC Human Genetics Unit in Edinburgh, funded by the Medical Research Council. This post will study the physiological relevance and the regulation of the nonsense-mediated mRNA decay (NMD) pathway in vivo.This post is full-time (35 hours per week). The salary for this post is £40,497 to £48,149 per annum.Your skills and attributes for success:

• PhD or equivalent in a relevant scientific discipline.

• Experience in Biochemistry, and RNA quality control.

• Experience in mouse genetics.

Click to view a copy of the full job description (opens new browser tab).Application InformationWe aim to understand regulatory mechanisms related to the processing and quality control of RNAs in vivo, focusing on the NMD pathway. Our recent development of mouse models harbouring an NMD biosensor will allow us to develop in vivo CRISPR screens to identify novel NMD factors, which will unveil the complex regulation and physiological relevance of the NMD pathway in vivo.This position will be part of a multidisciplinary team working on the molecular, biochemical, and cellular aspects of RNA processing in eukaryotes. The group is part of the MRC HGU and provides opportunities to develop research project skills and develop collaborative links with colleagues within the Institute and elsewhere. The MRC Human Genetics Unit is a highly multidisciplinary environment and is part of the Institute of Genetics and Cancer (IGC).Further details of the Research group’s work are available at:Please ensure you include the following documents in your application:

• CV

• Cover letter

As a valued member of our team you can expect:

• A competitive salary.

• An exciting, positive, creative, challenging and rewarding place to work.

• To be part of a diverse and vibrant international community.

• Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our

(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits.Championing equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab).The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.Key dates to noteThe closing date for applications is 16th April 2025.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.About Us: As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:A deep understanding of human genome function – particularly for the non-coding genome – is an outstanding grand challenge. Our mission is to discover how our genome controls the function of molecules, cells and tissues, in health and disease, connecting human genetic variation to phenotype.Multidisciplinary HGU research programs embrace genetic, computational, biochemical, cellular, model organism and clinical approaches, to gain meaningful insights across scales and dynamic processes, with cross-cutting themes in 4D Cellular Medicine and Genome Interpretation.To find out more visitThe MRC Human Genetics Unit is part of the Institute of Genetics and Cancer (IGC). This partnership with CRUK Edinburgh Centre and Centre for Genomic and Experimental Medicine Centre aims to understand development and disease by using the latest developments in genetic, genomic, cellular and clinical science. The partnership provides access to state of the art scientific facilities, scientific infrastructure and business support, including on site Advanced Imaging Resource, Animal Model support, Bioinformatics Analysis Core, DNA sequencing, Flow Cytometry, Mass Spectrometry, HTPU microarray. The IGC also offers a highly collegial environment with excellent local career development support, active social, wellbeing and sustainability related groups making it a very desirable and supportive working environment.To find out more visit

Expected salary

£40497 – 48149 per year

Location

Edinburgh – Midlothian

Job date

Fri, 04 Apr 2025 03:58:36 GMT

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