Research Fellow

Job title:

Analysis Fellow

Firm

College School London

Job description

About us The mission of the UCL Nice Ormond Road Institute of Baby Well being is to enhance the well being and well-being of youngsters, and the adults they are going to change into, via world-class analysis, training and public engagement. The UCL GOS ICH, along with its scientific accomplice Nice Ormond Road Hospital for Kids, kinds the most important focus of youngsters’s well being analysis exterior North America. GOS ICH’s actions embrace energetic engagement with kids and households, to make sure that our work is related and applicable to their wants. GOS ICH generates the funding for our analysis by setting out our proposals in prime quality functions to public, charitable and industrial funding our bodies and disseminates the outcomes of our analysis by publication within the medical and scientific literature, to clinicians, coverage makers and the broader public. The Institute gives world-class training and coaching throughout a variety of instructing and life studying programmes which tackle the wants of scholars {and professional} teams who’re taken with and endeavor work related to little one well being.

Concerning the position Candidates are invited for a 3-year post-doctorate analysis challenge funded by Kids with Most cancers UK. On this challenge you’ll work on the UCL Nice Ormond Road Institute of Baby Well being beneath supervision of Prof Owen Williams. The goals of this challenge are to judge the efficacy of novel therapies and clinically related brokers utilizing Acute Myeloid Leukaemia (AML) patient-derived xenograft fashions in vitro and in vivo, to determine genes and pathways whose disruption sensitises AML cells to novel therapeutics, and to find out mechanisms governing resistance and elevated sensitivity to transcription issue perturbation in AML cells. This challenge is predicated on our revealed analysis figuring out potent anti-AML exercise of mebendazole, via focusing on the transcription issue c-MYB for proteasomal degradation (Walf-Vorderwülbecke et al, 2018 Leukemia 32:882).

The challenge will contain lentiviral CRISPR drop-out screens and leukaemia co-culture fashions. Via this analysis we purpose to determine novel therapies that may finally enhance the outcomes of youngsters recognized with this aggressive illness.

The wage supplied on this position is £40,524 – £43,847 each year and is funded for 3 years within the first occasion.

About you Expertise in tissue tradition and molecular biology is crucial, and expertise with in vitro and in vivo most cancers assays is a bonus. Candidates should have (or at the least submitted) a PhD in experimental biology. Earlier expertise with a productive monitor document within the most cancers biology analysis discipline is strongly advisable. People with out such expertise, however with an distinctive monitor document in productive analysis in associated areas, are additionally inspired to use.

What we provide In addition to the thrilling alternatives this position presents we additionally provide some nice advantages a few of that are beneath:

41 Days vacation (together with 27 days annual depart 8 financial institution vacation and 6 closure days)
Outlined profit profession common revalued earnings pension scheme (CARE)
Cycle to work scheme and season ticket mortgage
On-Website nursery
On-site fitness center
Enhanced maternity, paternity and adoption pay
Worker help programme: Employees Help Service
Discounted medical insurance coverage

Our dedication to Equality, Variety and Inclusion As London’s World College, we all know range fosters creativity and innovation, and we would like our group to symbolize the range of the world’s expertise. We’re dedicated to equality of alternative, to being truthful and inclusive, and to being a spot the place all of us belong.

We subsequently significantly encourage functions from candidates who’re more likely to be underrepresented in UCL’s workforce.

These embrace individuals from Black, Asian and ethnic minority backgrounds; disabled individuals; LGBTQI+ individuals; and for our Grade 9 and 10 roles, ladies.

You may learn extra about our dedication to Equality, Variety and Inclusion right here : https://www.ucl.ac.uk/equality-diversity-inclusion/

Obtainable paperwork

Anticipated wage

£40524 – 43847 per 12 months

Location

North West London

Job date

Fri, 08 Mar 2024 03:42:54 GMT

To assist us monitor our recruitment effort, please point out in your electronic mail/cowl letter the place (globalvacancies.org) you noticed this job posting.