Research Fellow

The Faculty of Organic Sciences at Queen’s College Belfast, is at the moment looking for to recruit a gifted Analysis Fellow in Quantitative Interplay Proteomics and Chemoproteomics.

An skilled and motivated postdoctoral scientist is sought to hitch the Collins Lab (https://collinslab.web/ ) within the Faculty of Organic Sciences at Queen’s College Belfast. The profitable candidate will undertake a senior function within the planning and supply of analysis exercise centered on quantitative interplay proteomics and information impartial acquisition (DIA) mass spectrometry.

Our analysis group focuses on (i) growth of latest methodology in DIA mass spectrometry1,2 , (ii) strategies to characterize dynamic reorganization of protein complexes/interactions utilizing each focused and international approaches3,4 , and most lately (iii) the applying of those strategies in chemical biology and drug discovery, and (iv) the applying of those strategies to issues in varied illness settings together with innate immunity, most cancers, and host-pathogen interactions. This function will concentrate on the event and software of methods to quantify protein advanced reorganization in signalling methods. This can embody of neo protein-protein interactions by chemical induced proximity related within the context of early-stage drug discovery.

The profitable candidate can have a demonstrated monitor document in mass spectrometry-based proteomics analysis with a wonderful PhD diploma awarded and robust publication document. The profitable candidates can have tasks in impartial analysis, supervision, planning, day-to-day lab administration, collaborations, and outreach. The function will embody entry to newly established functionality throughout the new Chemoproteomics Centre of Excellence located inside QUB (https://bit.ly/chemoprot ).

References: 1 Meier, F. et al.Nature Strategies 17, 1229 (2020) 2 Collins, B. C. et al.Nature Communications 8, 291 (2017) 3 Collins, B. C. et al.Nat Meth 10, 1246 (2013) 4 Heusel, M. et al.Cell Programs 10, 133 (2020).

The profitable candidate should have, and your software ought to clearly display that you simply meet the next standards:

Have or about to acquire* a PhD in quantitative proteomics, mass spectrometry, or a associated self-discipline. (* inside 3 months of graduation of put up).

Substantial related analysis expertise in growing and making use of mass spectrometry-based quantitative proteomics strategies.

Peer reviewed publications or preprints within the space of mass spectrometry-based proteomics.

Expertise within the basic upkeep and technical troubleshooting of mass spectrometry devices.

Expertise in pattern preparation and separations for mass spectrometry-based proteomics.

Sensible expertise in processing, recording and dealing with information units, and performing statistical evaluation.

Sturdy publication document in peer reviewed journals.

Expertise with information evaluation utilizing scripting (e.g. R, python, unix).

Please be aware the above should not an exhaustive listing. For additional details about the function please go to our web site.

This can be a mounted time period put up accessible for 21 months (anticipated begin by 1 June 2024. Mounted time period contract posts can be found for the said interval within the first occasion however specifically circumstances could also be renewed or made everlasting topic to availability of funding.

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