University College London
Job title:
Research Fellow
Company
University College London
Job description
About usOur pioneering research has significantly advanced the understanding of autoimmune diseases, particularly through her discoveries in the fields of gut dysbiosis, immune regulation, and regulatory B cells (Bregs). Mauri’s groups work has revealed that gut dysbiosis—an imbalance in the gut microbiome—can lead to increased gut permeability, allowing microbial components to breach the intestinal barrier and trigger autoimmune responses. Her research has shown that this breakdown in gut integrity plays a critical role in the development and exacerbation of autoimmune diseases.Equally transformative are her findings on regulatory B cells (Bregs), a specialized subset of B cells that help maintain immune tolerance by suppressing excessive immune responses. Mauri has demonstrated that Bregs are crucial in controlling inflammation and autoimmunity, particularly in their ability to produce anti-inflammatory cytokines like IL-10. Her work has highlighted the potential of modulating Bregs to restore immune balance in patients with autoimmune disorders. These discoveries have placed Mauri at the forefront of immunological research, positioning her work as a foundation for developing novel therapeutic strategies targeting both gut health and immune regulation in autoimmune diseases.We now aim to combine our immunological expertise to identify in detail how B cells contribute to the maintenance of gut-specialized epithelial cell health and what goes awry in rheumatoid arthritis (RA)About the roleThe successful candidate will join a dynamic group of basic and clinical scientists all working on integrated aspects of the immunopathogenesis and immunotherapy of autoimmune diseases with particular emphasis on Rheumatoid Arthritis (RA) and Systemic Lupus Erythematous (SLE).The position is available until 2027 in the first instance.Note: Appointment at grade 7 is dependent upon having been awarded a PhD; if this is not the case, the initial appointment will be at research assistant Grade 6B, with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.About youThe post holder will be an enthusiastic post-doctoral researcher, expected to perform high quality research under the direction of the principal investigator, Claudia Mauri, working closely with Professor Mario Zaiss and Dr Madura Castelino (Rheumatology consultant). They will also interact closely with the second post-doctoral researcher funded by this grant and with PhD funded by the MRC-DTP scheme as well as with many clinical collaborators. We are seeking highly motivated individuals with the ability to generate their own research strategies and pursue them with determination, flexibility and creativity.Please see the attached job description and person specification for full details. Please also read the attached Candidate Guidance document.All applications must include a supporting statement telling us, using examples, how you meet the essential criteria listed in the job description. Applications without a supporting statement will be rejected.If you have any queries about the role or application process, have any technical issues, or need reasonable adjustments or a more accessible format to apply for this job online, please contact the staffing team atWhat we offerAs well as the exciting opportunities this role presents, we also offer great benefits some of which are listed below:
- 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- Immigration loan
- Relocation scheme for certain posts
- On-Site nursery
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
- Discounted medical insurance
Visit to find out more.Our commitment to Equality, Diversity and InclusionAs London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce.These include people from Black, Asian, and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.Available documents
Expected salary
Location
North West London
Job date
Wed, 04 Sep 2024 02:50:24 GMT
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