Research Fellow

Job title:

Research Fellow

Company

University College London

Job description

About usThe RNA Regulation Laboratory, headed by Prof Andres Ramos is a highly dynamic research environment that applies a multi-disciplinary approach to address key questions in RNA Biology and neuronal regulation. The laboratory is part of the Biosciences Division, a centre of research excellence and one of the largest Divisions within UCL. Research activities in the Division and the linked Institute of Structural and Molecular Biology are underpinned by state-of the-art research facilities hosting and developing methodologies, including laboratories for X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, single molecules methods, cell biology, optical microscopy, bioinformatics and ion mobility mass spectrometry. The Division coordinates a range of undergraduate and master programmes, and host a large number of postgraduate research students funded by MRC, BBSRC, EPSRC and many others. Symposia, retreats and seminar series are an important part of the experience of our community.The Ramos lab promotes independent, creative, thinking, and projects are often in collaboration. The project we propose is an exciting opportunity to explore the role that RNA regulation plays in neuronal development at the molecular level, integrating structural biology, NMR and biophysical data with data on in cell interactions and function.About the roleThe research we propose will focus on understanding the molecular basis of regulation in local mRNA translation and neuronal development. Important questions include, but are not limited to, how the regulatory proteins recognise a diverse network of mRNAs targets encoding for microtubule proteins, how phosphorylation signals regulate the proteins’ activity and how the proteins recruit the mRNA to the transport machinery. To study the complex, dynamic, regulatory systems involved, the role holder will use NMR, including developing ad hoc NMR methodology, but also a range of other structural biology and biophysical methods. They will liaise with a network of collaborators and work closely with a cell biologist and a technician funded by the grant. They will pursue original multidisciplinary research and be an active member of the Ramos lab.This is an open ended contract for 30 months from the start date, in the first instance.Research Fellows – ‘Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B (salary £34,502 – £36,348 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD Thesis.’This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit for more information.A job description and person specification can be accessed at the bottom of this page.If you have any queries about the role, please contact Andres Ramos at .If you need reasonable adjustments or a more accessible format to apply for this job online or have any queries about the application process, please contact Biosciences staffing at biosciences.staffing@ucl.ac.uk.About youYou must have a PhD in structural biology, biophysics or a related subject area and proven knowledge of NMR and its application to the study of macromolecules. Experience in protein and RNA biochemistry, methods to detect protein-RNA interactions, and basic cell biology is also important. You will be expected to work as part of a tightly integrated team to produce original contributions to the mechanistic understanding of the role of RNA regulators in neuronal development. Your studies will focus on the understanding of the IGFBP1/IMP1 system, in the first instance. In addition to developing and conducting the research, you will contribute expertise to the overall research effort in the Ramos group. You will also communicate results as scientific papers in leading journals, and as scientific presentations at national and international conferences.What we offerAs well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit to find out more.Our commitment to Equality, Diversity and InclusionAs London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce.These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.Our department holds an Athena SWAN Silver award, in recognition of our commitment to advancing gender equality.You can read more about our commitment to Equality, Diversity and Inclusion here:Available documents

Expected salary

£34502 – 36348 per year

Location

North West London

Job date

Fri, 27 Sep 2024 01:20:53 GMT

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