Research Fellow

Job title:

Research Fellow

Company

University College London

Job description

About usThe UCL Huntington’s Disease Centre, based in the Department of Neurodegenerative Disease, is uniquely placed world-wide to translate mechanistic insights to ‘first in human’ studies. It combines sophisticated cell-based systems with rigorously standardised preclinical target validation to prime mechanistically-driven drug development initiatives. The Centre integrates clinical and laboratory work with small proof-of-concept first in human studies in patients in the Leonard Wolfson Experimental Neurology Centre (LWENC) prior to initiating larger phase 2 and 3 clinical trials including novel huntingtin-lowering trials.About the roleWe are recruiting a Research Fellow to contribute to a project examining the role of the HD genetic modifier PMS1 within Professor Sarah Tabrizi’s research group at the Huntington’s Disease Centre.You will help determine whether PMS1 expression or specific functions of the protein can modify somatic expansion of the HTT CAG repeat region. You will also assess whether therapeutic targeting of PMS1 expression via small molecule-based lowering can modify this phenotype.This is an internal recruitment advert, available to eligible UCL workers only. The post is offered part-time at 5.475 hours per week (0.15 Full Time Equivalent).The role is available immediately and is funded by a research grant from Rgenta Therapeutics until 31 August 2025.If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team ( ).Informal enquiries regarding the role can be addressed to Professor Sarah Tabrizi ( ).A full job description and person specification for this role can be accessed below.About youYou’ll have a PhD in a relevant biological discipline or related subject area and experience of working in experimental laboratory research, with tissue culture, and with molecular biology (including PCR assays and transduction/transfection of cells). Proactivity, strong problem-solving abilities, and excellent communication skills are also essential for this role.This role does not meet the eligibility requirements for a Skilled Worker Visa certificate of sponsorship under UK Visas and Immigration legislation. Therefore UCL will not be able to sponsor individuals who require right to work in the UK to carry out this role.What we offerStarting salary offered in the range of £6,468.60 – £6,805.80 (i.e., 15% of £43,124 – £45,372) per annum, inclusive of London Allowance.Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £5,753.55 – £6,150.75 [i.e., 15% of £38,357 – £41,005] per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• On-site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit to find out more.This appointment is subject toOur commitment to Equality, Diversity and InclusionThe Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our for more information about our initiatives and priorities. The Institute also holds an , in recognition of our commitment and demonstrable impact in advancing gender equality.As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 rolesAvailable documents

Expected salary

Location

North West London

Job date

Wed, 13 Nov 2024 00:49:28 GMT

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