Research Fellow


About us

The mission of the UCL Great Ormond Street Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of! teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health.

About the role

This post has been funded by Action Medical Research. The title of the project is ‘Restoring Normal Ciliary Function in Primary Ciliary Dyskinesia: A Novel High-Content Drug Screening Approach to Overcome Nonsense Mutations in Rare Respiratory Disease’. Primary Ciliary Dyskinesia causes severe and progressive lung damage in children and adults and is an area of emerging focus in the scientific community. This project builds on previous work attempting to restore ciliary function that is defective, which has the potential to greatly improve clinical outcomes. The project focuses on overcoming nonsense mutations that account for 30 per cent of those affected. The successful postdoc will lead the laboratory research using human PCD ciliated cell culture models, exposing them ! to potent ial therapies that read through nonsense mutations and inhibit nonsense-mediated decay. This will include research into improving cellular drug delivery using lipid nanoparticles. The postdoc will work with other research staff who are focusing on alternative strategies to restore ciliary function. The salary for this post is £39,508 pa and this post is available until 28/02/2025 in the first instance with possible extension until 30/06/2025.

About you

The post holder will have a PhD in relevant subject, substantial cell culture experience, and genetic experience. Experience in ciliary function analysis, confocal microscopy and cellular drug delivery are desirable.

What we offer:

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Our commitment to Equality, Diversity and Inclusion

At GOS ICH we aim to always have a balanced interview panel that is representative of gender and ethnic diversity. We! particul arly welcome female applicants and those from an ethnic minority, as they are under-represented within UCL at this level. UCL Taking Action for Equality If you have any queries regarding the application process, please contact Madhur Sharma on quoting job reference

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