Research Fellow (Computational Biology)

Job title:

Research Fellow (Computational Biology)

Company

University College London

Job description

About usThe Department of Neuromuscular Diseases is a hub for clinical and research excellence across the spectrum of spinal cord and neuromuscular diseases. Our group of world-leading clinical, genetic and basic science researchers focus their work on understanding the causes and biological mechanisms leading to Neuromuscular Disease and translating this knowledge into developing novel therapeutic solutions that is of direct benefit to neurological disorders such as motor neurone disease, Alzheimer’s disease and neuromuscular disease.The Patani Lab, based in the Department, aims to understand the molecular and cellular mechanisms underpinning motor neuron disease (ALS). We use a variety of patient derived iPSC lines to investigate disease-related events at molecular level across different relevant cell types, including motor neurons, astrocytes and microglia.About the roleWe are seeking a talented and highly motivated computational biologist (Postdoctoral Research Fellow) to join our established and dedicated team of researchers using human induced pluripotent stem cells to study Motor Neuron Disease (ALS).Based in the laboratory of Professor Rickie Patani, you will be joining a team of experimental scientists working on resolving the molecular basis of motor neuron degeneration with a particular focus on the relationship between DNA damage and aberrant RNA metabolism using established human stem cell models of ALS. As main bioinformatician working on the project, you will analyse diverse datasets deriving from cutting-edge sequencing approaches (such as DRIP-seq, INDUCE-seq and bulk RNAseq, etc.), to explore the complex functional interaction between these processes. This exciting project is developed as part of an established collaboration with Prof. Simon Boulton’s lab at the Francis Crick Institute.This is a compelling opportunity to contribute to ground-breaking, high-impact research projects within an intellectually stimulating, globally diverse scientific community.The role is available immediately and funded by My Name’5 Doddie Foundation for two years in the first instance.If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team ( ).Informal enquiries regarding the role can be addressed to Professor Rickie Patani ( ).A full job description and person specification for this role can be accessed below.About youYou will have a PhD in a relevant subject (computational biology, bioinformatics, statistics, neuroscience, etc.), and significant computational experience in mathematical modelling of complex biological data and in using R/Python and/or other programming languages. Proven experience analysing bulk RNAseq datasets, with specific focus on splicing and RNA processing is also required for this job.This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.What we offerStarting salary offered in the rage £42,099 – £49,263 per annum.Appointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant (salary £37,332 – £39,980 per annum) with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis.As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• Relocation scheme for certain posts
• On-site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit to find out more.This appointment is subject to .Our commitment to Equality, Diversity and InclusionThe Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our for more information about our initiatives and priorities. The Institute also holds an , in recognition of our commitment and demonstrable impact in advancing gender equality.As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.Available documents

Expected salary

£42099 – 49263 per year

Location

North West London

Job date

Sun, 28 Apr 2024 00:15:06 GMT

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