Research Fellow in Biophysics of Amyloid Formation
University of Leeds
Research Fellow in Biophysics of Amyloid Formation
Astbury Centre for Structural Molecular Biology
School of Molecular and Cellular BiologyAre you an ambitious researcher looking for your next challenge? Do you have an established background in biophysical analysis of amyloid formation mechanisms and want to help to develop new routes to combat amyloid diseases? Do you want to further your career in one of the UKs leading research intensive Universities?We are looking for an outstanding postdoctoral research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, using α-synuclein as a model system. This role will use NMR spectroscopy, combined with other biochemical, biophysical and computational methods, to understand how the properties of the initially disordered α-synuclein monomer funnels its self-assembly into different polymorphic amyloid structures. In parallel, you will use C. elegans as a model organism to follow aggregate formation of α-synuclein and its natural variants in a living organism.You will be based in the laboratory of Professor Sheena Radford and work closely with our collaborators and other members of the amyloid team (funded by Wellcome, BBSRC and the Royal Society). You should have a PhD (or be close to completing one) in Structural Biology, Biophysics, Biochemistry, or a related discipline, and you should have extensive experience of using biophysical and computational methods to elucidate biological mechanisms. Experience of working in the amyloid field is required.What we offer in return
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Thu, 21 Nov 2024 02:34:55 GMT
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