Research Fellow in Molecular Biology and Bioprocessing of Cellular Immunotherapies

Job title:

Research Fellow in Molecular Biology and Bioprocessing of Cellular Immunotherapies

Company

University College London

Job description

About us We are recruiting a proactive, collaborative and highly motivated Research Fellow to join the Cell and Gene Therapy Bioprocessing Group at UCL and lead research in Molecular Biology and Bioprocessing of Cellular Immunotherapies. The successful candidate will be lead postdoctoral researcher as part of SMARTCell Scalable Manufacture of Advanced Regenerative Cellular Therapies project.The aim of the SMARTCell project is to establish a scalable manufacturing process for allogeneic gene-modified cellular and demonstrate consistent, multi-litre scale production for cellular immunotherapies with the goal of improving the production process and increase the quantity and quality of cell manufacture.The investment in the UCL Biochemical Engineering’s cell and gene therapy research exceeds £10m and focuses on cellular immunotherapy bioprocessing, gene delivery and gene therapy and non-viral technologies. The Research Fellow will be joining the CGTB group which comprises of >10 doctoral researchers and four postdoctoral Research Fellows. This advertised role would be an additional Research Fellow to the group and there would be the opportunity for the successful candidate to manage and lead projects and activities within the wider group.This post is funded for 2.5 yearsAbout the role The primary role of the Research Fellow will be to execute and lead experimental studies investigating the scale-up and production of allogeneic gene-modified cellular immunotherapies (e.g. allo CAR-T and/or CAR-NK). This will include the identifying the optimal cell source for allogeneic cellular immunotherapy manufacture, gene-editing/gene delivery for allogeneic applications and development of scalable cell culture processes. This will include investigating the role of critical process parameters and key variables that impact cell product quality and yield, and require the candidate to have a strong track record in molecular biology, experimental design and bioprocessing. The candidate will be required work independently to prepare and conduct rigorous and scientifically robust research. The role will require an awareness of current Good Manufacturing Practice (cGMP) as required by health regulators as well as a strong understanding of the commercial and regulatory implications of the work. With respect to T and/or NK-cell bioprocessing, it is expected the candidate will be familiar with the fundamental biology and simplifying and optimising the isolation of these cells in addition to their upstream/downstream processing, characterisation and cell analysis.In addition to leading their own research plan, the role will provide significant management and industrial engagement opportunities. The Research Fellow will support the management of the CGTB Group, including support of the doctoral students and liaising with external partners.About you To succeed in this role you will have:

• A PhD awarded (or about to be) in a relevant subject. This may include biological sciences, cell biology or immunology disciplines, biotechnology or biochemical engineering with relevance to cell culture, bioprocessing and analytics, and an interest in developing an understanding of scalable manufacture of allogeneic cellular immunotherapies.
• Experience immune cell culture and analytics for cellular immunotherapy applications. • Training and experience in working in cell process development including the use of bioreactors.
• Experience with cell characterisation assays including flow cytometry, ELISA, qPCR and other relevant assays for cellular immunotherapies.

What we offer As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit https://www.ucl.ac.uk/work-at-ucl/rewards-and-benefits to find out more.Our commitment to Equality, Diversity and Inclusion As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce.These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusionAvailable documents

Expected salary

Location

North West London

Job date

Thu, 26 Sep 2024 02:29:09 GMT

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