Research Fellow (Microglia and immunity in Alzheimer’s Disease)

Job title:

Research Fellow (Microglia and immunity in Alzheimer’s Disease)

Company

University College London

Job description

About usThe (UK DRI) is the biggest UK initiative supporting research to fill the major knowledge gap in our basic understanding of the diseases that cause dementia.The De Strooper/Arancibia Lab focuses on understanding the fundamental mechanisms that underlie neurodegenerative disease, with a particular interest in the cellular phase of Alzheimer’s disease, the neuro-immune axis and single cell genomics.Bart De Strooper’s lab is divided between Leuven, Belgium and the Francis Crick institute in London, embedded in both vibrant research communities with extensive access to state-of-the-art support, infrastructure, and collaborations.About the roleWe are looking for a postdoctoral Research Fellow interested in the cell biology of microglia in Alzheimer’s Disease to join the lab and work on a project focusing on understanding the effect of gene alterations on the microglia responses in Alzheimer’s disease. We are particularly interested in the endosomal-phagocytosis and antigen presentation roles of microglia in the context of amyloid pathology and how microglia dysfunction affects neuronal cells and the role of the SORL1 gene herein.You will work at the interface between computational teams (based at both the Francis Crick Institute and VIB, Leuven) and wet lab groups. The role offers the opportunity to further develop yourself as an expert in the field of neurodegenerative diseases. This is an excellent opportunity to work on high impact, state-of-the-art projects in a stimulating and social international research environment, undertaking world-class science under the guidance of a leader in Alzheimer’s biology.The post is available immediately and funded by the UK DRI for three years or until 31 July 2027, whichever is earlier, in the first instance.If you need reasonable adjustments or a more accessible format to apply for this job online, or have any queries regarding the application process, please contact the Institute of Neurology HR Team ( ).A full job description and person specification for this role can be accessed below.About youYou’ll hold a PhD degree in cell biology, immunology, neuroscience, or a related area, and have extensive knowledge of molecular biology, cell biology, neurodegenerative disease, or related subjects. Experience with cell culture and cell biology, including a good understanding of the endo-lysosomal pathways and/or antigen presentation, is essential, as are good interpersonal skills, the ability to work in a diverse group including computational and experimental neurobiologists, and the ability to organise your own work without extensive supervision.This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.What we offerAppointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant (salary £37,332 – £39,980 per annum) with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis.As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• On-site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit to find out more.This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit for more information.Our commitment to Equality, Diversity and InclusionThe Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our for more information about our initiatives and priorities. The Institute also holds an , in recognition of our commitment and demonstrable impact in advancing gender equality.As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.Available documents

Expected salary

£37332 – 39980 per year

Location

North West London

Job date

Fri, 14 Jun 2024 23:31:36 GMT

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