Research Fellow

Contract Type: Fixed Term contract up to June 2027

We are seeking to recruit a Research Fellow at the School of Dentistry, University of Birmingham, with state of the art research facilities, working with Prof. Gabriel Landini and Dr Richard Shelton.

This is 4-year collaborative project between the University of Birmingham and the University of Oxford, funded by the EPSRC aiming to develop understanding of enamel demineralisation to combat human dental caries.  Research will be directed towards the following four areas of research:

1) Procuring samples with incipient and artificial caries to be prepared for assessment by conventional high  resolution techniques (SRCT, FIB-SEM, AFM, TEM). Prepare and analyse artificial demineralised lesions obtained under various etching conditions with multi-scale match to prototypes.

2) Top-down 4D characterisation of enamel structural evolution using macro- using multiple techniques at macro-, micro- and nano- scale resolution in macro- and micro-fluidics setups to observe enamel etching. Use ‘zoom’ tomography and imaging to resolve structural variation across scales from 30μm down to 3nm to establish a platform for reverse bottom-up enamel remineralisation.

3) Bottom-up multi-modal 4D observation of HAp biological and/or chemical remineralisation. Evaluate enamel demineralisation kinetics in fluidic setups, accelerated/enhanced pathways to enamel-like apatite deposition using biological and mineral means (e.g. chemical precipitation, peptide-driven regeneration and electrophoretic deposition). Use multi-modal, multi-scale 4D microscopy (SEM, AFM, SRCT) for the analysis of the evolution of globule formation, crystal nucleation, self-assembly and growth from ions clusters to polycrystals.

4) Liaise with the collaborators to develop multi-scale, multi-physics reaction-diffusion modelling of HAp dissolution/precipitation to include liquid-solid interaction and evolving environment (pH), transport (specific ion concentrations, dissolution/precipitation conditions) and structure (morphology, size, orientation) of HAp crystallites.

Ideal candidates will have a good first degree in biomedical or bioengineering related subjects with a strong background and a PhD (or near to completion) in a subject relevant to the project (previous experience in histology, hard tissue specimen preparation, microscopy, image analysis, micro-CT or synchrotron imaging would be advantageous).

For informal enquires, please contact Prof. G. Landini at [email protected]  or Dr. R. Shelton [email protected]  

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