Research Opportunities – Pediatrics

Scheduled Hours
40

Place Abstract
The Perlmutter lab is searching for a proficient and motivated particular person to affix our workforce within the Division of Gastroenterology, Hepatology, & Diet of the Division of Pediatrics. The lab’s focus is analysis on the pathobiology of, and coverings for, α1antitrypsin deficiency (ATD), a uncommon illness wherein a misfolded protein causes liver fibrosis/most cancers by gain-of-toxic perform and continual obstructive lung illness by loss-of-function. One of many main areas of focus is autophagy enhancer medication to clear the poisonous misfolded protein.
During the last 10 years the lab has refined using cell line and mouse fashions for testing of recent drug methods, now primarily on autophagy enhancer medication. This work additionally now includes a novel C. elegans mannequin of antitrypsin deficiency that has been tailored to high-content screening of drug and RNAi libraries for brand new therapies for different protein aggregation issues. The lab has now recognized a lead candidate autophagy enhancer drug with in vivo efficacy for ATD and likewise efficacy in mobile fashions of Huntington’s illness and frontotemporal dementia (tauopathy) and therein imagine this drug collection will likely be splendid for the tauopathy of continual traumatic encephalopathy.
PMID: 38336172, 308066314, 37214956, 36848094.

Job Description

Extra details about the Perlmutter Lab is obtainable right here: https://pediatricgi.wustl.edu/objects/perlmutter-lab/ .

Working Circumstances

This place works in a laboratory setting with potential publicity to organic and chemical hazards. The person have to be bodily capable of put on protecting gear and to offer commonplace care to analysis animals.

Wage Vary

Base pay is commensurate with expertise.

Most well-liked {Qualifications} 

• Efficient verbal, written, and interpersonal communication expertise.
• Demonstrated talents with the Microsoft Workplace Suite.
• Efficient group expertise and skill to prioritize workload.
• Demonstrated skill to work independently and talk with laboratory employees and investigators. 
• Potential to keep up full and arranged data/experiences. 
• Working data of laptop software program and basic lab gear.

Required {Qualifications}

• Bachelor’s diploma. Candidates with extra training and expertise are inspired to use.
• Prior vital expertise with not less than one, ideally two, of the next strategies is required:
  • Cell tradition
  • Immunoblot evaluation
  • SiRNA and different gene switch strategies for cell traces
  • Protein expression and purification

Grade

Wage Vary

The wage vary displays base salaries paid for positions in a given job grade throughout the College. Particular person charges throughout the vary will likely be decided by components together with one’s {qualifications} and efficiency, fairness with others within the division, market charges for positions throughout the similar grade and division funds.

Questions

For ceaselessly requested questions in regards to the software course of, please discuss with our Exterior Applicant FAQ .

Lodging

In case you are unable to make use of our on-line software system and would really like an lodging, please e-mail [email protected]  or name the devoted lodging inquiry quantity at 314-935-1149 and depart a voicemail with the character of your request.

Pre-Employment Screening
All exterior candidates receiving a proposal for employment will likely be required to undergo pre-employment screening for this place. The screenings will embody prison background examine and, as relevant for the place, different background checks, drug display, an employment and training or licensure/certification verification, bodily examination, sure vaccinations and/or governmental registry checks. All presents are contingent upon profitable completion of required screening.

Advantages Assertion

Private

• As much as 22 days of trip, 10 acknowledged holidays, and sick time.

• Aggressive medical health insurance packages with precedence appointments and decrease copays/coinsurance.

• Need to Dwell Close to Your Work and/or enhance your commute? Reap the benefits of our free Metro transit U-Cross for eligible staff. We additionally supply a forgivable house mortgage of as much as $12,500 for closing prices and a down cost for houses in eligible neighborhoods.

• WashU supplies eligible staff with an outlined contribution (403(b)) Retirement Financial savings Plan, which mixes worker contributions and college contributions beginning at 7%.

Wellness

• Wellness challenges, annual well being screenings, psychological well being sources, mindfulness applications and programs, worker help program (EAP), monetary sources, entry to dietitians, and extra!

Household

• We provide 4 weeks of caregiver depart to bond together with your new youngster. Household care sources are additionally out there on your continued childcare wants. Want grownup care? We’ve obtained you coated.

• WashU covers the price of tuition for you and your loved ones, together with dependent undergraduate-level school tuition as much as 100% at WashU and 40% elsewhere after seven years with us.

For insurance policies, detailed advantages, and eligibility, please go to: https://hr.wustl.edu/advantages/

EEO/AA Assertion
Washington College in St. Louis is dedicated to the ideas and practices of equal employment alternative and particularly encourages functions by these from underrepresented teams. It’s the College’s coverage to offer equal alternative and entry to individuals in all job titles with out regard to race, ethnicity, shade, nationwide origin, age, faith, intercourse, sexual orientation, gender id or expression, incapacity, protected veteran standing, or genetic info.

Range Assertion
Washington College is devoted to constructing a various neighborhood of people who’re dedicated to contributing to an inclusive setting – fostering respect for all and welcoming people from numerous backgrounds, experiences and views. People with a dedication to those values are inspired to use.