Research Technician


14 Jun 2023
Job Information

Research Field
Medical sciences
Researcher Profile
Recognised Researcher (R2)
First Stage Researcher (R1)
United Kingdom
Application Deadline
15 Jul 2023 – 00:00 (UTC)
Type of Contract
Job Status
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

Offer Description

Job description

A research technician is required to provide laboratory support for a project on “Mechanisms of Ventral Closure”. Ventral closure (VC) is a late morphogenetic event in embryonic development whose failure leads to the birth defects omphalocoele and gastroschisis. The project will ask how VC happens or fails, specifically what are the cellular events and molecular regulators that make the abdominal wall grow around the viscera.   

The technician will work in the Jeremy Green and Philippa Francis-West labs at King’s College London. The labs are well-established and located in the vibrant and supportive environment of the Centre for Craniofacial Regenerative Biology on the Guy’s Hospital Campus.   

The technician will be responsible for establishing and maintaining colonies of mice expressing fluorescent markers and both genetically modified mice causing VC defects. In addition, the technician will contribute to the research on the project and support the cellular, molecular and immunohistological work carried out in the project, including explant culture and data analysis of cell proliferation, cell death and cell shape in the abdominal wall. The technician will work closely with the co-investigator Dr Caroline Formstone and with the Postdoc to aid project progression. Experience in mouse work is essential and an active Home Office Personal Licence or equivalent will be highly desirable. Experience in molecular techniques and/or microscopy will be an advantage.

Responsibilities will include general lab management tasks such as consumables ordering, lab database maintenance, etc.

The Department has over 60 research staff and occupies laboratories and core facilities on floor 27 of Guy’s Tower.  

This post will be offered on a fixed-term contract for 25 months 

This is a part-time  post – 50% full time equivalent

Key responsibilities

  • To establish and maintain colonies of genetically modified mice. 
  • To carry out research activities related to the project, including genotyping, immunohistochemistry, image annotation, tissue explant culture. 
  • To prepare solutions, help with ordering and aid the smooth running of the labs 
  • To work to an appropriate level of health and safety and perform such jobs as required for effective running of the laboratories. 
  • To maintain an up to date and comprehensible record of laboratory work, to make results accessible and complete. 
  • To work in a timely and organised fashion to complete pieces of work, produce reports or analyses or contribute to scientific discussion 
  • To manage the running of the labs: coordinating with Dr Formstone, Professor Francis-West and Professor Green. 

Skills, knowledge, and experience 

**Essential criteria **

  • BSc in Biomedical Sciences or equivalent, including knowledge of genetics 
  • Experience working with mice or similar animals 
  • Excellent written and verbal communication skills 
  • Good general lab skills  
  • Ability to work in a multidisciplinary team 
  • Problem solving skills 
  • Organised record keeping and experimental planning  

Desirable criteria

  • MSc or PhD level experience in a biomedical sciences subject 
  • Home office personal licence for working with mice or similar 
  • Experience in mouse colony maintenance  
  • Experience of embryology or organ culture 
  • Experience of Molecular biology techniques such as PCR and immunofluorescence 


Further information

For further information on the research project see Panousopoulou et al. J. Cell Sci. 2016 ( ) and Mao et al. Nature Comms. 2016 (https://doi: 10.1038/ncomms11469).  

Additional Information
Work Location(s)

Number of offers available
United Kingdom
London (Central)

Where to apply



London (Central)


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