Scientific Officer

Job title:

Scientific Officer

Company

Morson Talent

Job description

Job Title: Scientific OfficerStarting salary: circa £25,000 (dependent upon experience)
Duration: Fixed term until 31 March 2027
Location: ManchesterAbout the role:
We are currently looking for a Scientific Officer to join our National Biomarker Centre. The National Biomarker Centre (NBC) group at CRUK Manchester Institute holds a leading position in the field of cancer biomarker sciences. The NBC consists of multiple complementary teams, including the Preclinical Pharmacology (PP) team that uses a variety of preclinical cancer model systems to interrogate the biology and dependencies of different cancers. An integral part of this is the generation, development, and use of animal models of cancer, with a particular focus on patient-derived models. The aim of this post is to support the day to day running of the preclinical team and carry out research under supervision as directed by the Group Leader, Preclinical Pharmacology Team Leader and In Vivo Team Manager.About you:
You will have a BSc (or equivalent) in biology related discipline or have equivalent relevant experience and be a current or previous holder of a Home Office Personal Licence (PIL A and B) or equivalent under the Animals (Scientific Procedures) Act 1986. You will conduct in vivo preclinical pharmacology studies in collaboration with academic and industrial drug developers including the analysis of predictive and pharmacodynamic biomarkers. Ideally, you will have a basic knowledge of cancer biology along with experience in in vivo pharmacology and a strong desire to see their research translated for patient benefit.Our Centre discovers, develops, validates and qualifies biomarkers in clinical studies and trials that detect cancer earlier and predict and monitor therapy responses to support optimised treatment of patients with cancer. Our advanced research programmes, agnostic to cancer type, develop biomarkers in tissue and less invasive clinical samples such as blood (liquid biopsy) with sophisticated bioinformatic and artificial intelligence solutions for multi-modal laboratory and clinical biomarker data analysis and interpretation. Our preclinical programmes focus on development of pharmacodynamic biomarker and evaluation the efficacy of novel therapeutics in patient derived models. As a bridge between discovery science and clinical research, we are highly collaborative across Manchester, nationally and internationally.ORGANISATIONAL ARRANGEMENTSDay to day: I. NBC Preclinical in vivo team leader
Accountable to: I. NBC Preclinical in vivo team leader
II. NBC Preclinical Pharmacology Team Lead
III. NBC Group LeaderJOB PURPOSETo conduct in vivo research in the Preclinical Pharmacology team within the National Biomarker Centre, primarily supporting research using lung cancer mouse models. The post holder will work with members of the team to generate and maintain preclinical mouse models of human cancer and may also become involved in testing the models for response to therapy.DUTIES AND RESPONSIBILITIESUsing established protocols and procedures and with in-house training where required, plan and execute own work after discussion with the Preclinical in vivo Team Leader.All duties will be in accordance with the Animal (Scientific Procedures) Act 1986.The post holder will:

• Be expected to hold a Home Office Personal Licence and work in accordance with the Animal (Scientific Procedures) Act 1986.
• Prepare patient samples (usually blood or tumour tissue) for

in vivo use.

• Perform in vivo work including implanting cells for xenograft studies or patient tumour tissue for PDX studies, drug administration, tumour monitoring (this may involve occasional weekend

Expected salary

£26000 per year

Location

Manchester

Job date

Sat, 03 Aug 2024 22:44:49 GMT

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