Scientist II or Senior Scientist I – Drug Metabolite Identification in North Chicago, Illinois

Company Description

AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The Drug Metabolism and Disposition group in DMPK-BA has an open position for a Senior/Principal Research Scientist to lead drug metabolism and mass spectrometry imaging studies to support discovery and development. The selected candidate will be responsible for designing and conducting ADME investigations, interpret results, and apply knowledge to drive the pipeline and answer key scientific questions. In addition, the candidate will be responsible for the utilization and advancement of MALDI-MSI technology to develop our understanding of tissue distribution as related to safety assessment, metabolism, drug-drug interactions, pharmacokinetics, and pharmacology. The candidate will collaborate across various disciplines within AbbVie including DMPK, chemistry, biology, toxicology, pathology, clinical and regulatory to support biotransformation. The individual is expected to have a high level of practical experience in mass spectrometry, biotransformation, mass spectrometry imaging, analytical method development, metabolite profiling, handling radioactive compounds, technology development and possess strong written and oral communication skills. Duties are initially focused on laboratory work but will be expanded to broader responsibilities based upon interest, ability, and project needs.

Key Responsibilities Include:

• Design, perform, interpret, and report appropriate data from biotransformation and imaging studies for identifying metabolite structures, associated pathways, and distribution in tissues

• DMPK subject matter expert and provides clear data interpretation and strategy to DMPK colleagues, project teams and management

• Ensuring a world-class scientific approach to MS imaging by implementing and developing tools and processes.

• Leading scientific initiatives to improve MSI capabilities and combining other imaging techniques (histology, microscopy, and radio imaging) to support drug discovery and development.

• Routinely operate LC-MS/MS instrumentation, including maintenance and troubleshooting.

• Writing or contributing to study reports and regulatory submissions.

• Keeps well-informed of literature; Evaluate new methods, technologies, study designs and equipment.

• Utilizes expertise to direct projects and is visible outside of functional area

• Accepts supervision of associate scientists as required

• Provide training, development and guidance to staff.

Qualifications

• Motivated Ph.D. in life sciences with 10+ years, MS with 15+ years relevant academic or industry research experience in small molecule development.

• Expert in mass spectrometry and drug metabolism processes, including method development, metabolite profiling, metabolic processes, and related techniques

• Experience writing regulatory documentation is preferred

• Understanding of drug metabolizing enzymes, transporters, and pharmacokinetic principles is preferred.

• Broad experience in mass spectrometry imaging analysis on both small and large molecules

• Advanced training with radio-active material is preferred

• Strong interpersonal skills, the ability to work independently with minimal supervision in managing multiple projects and priorities and work well within a team

• Strong presentation and written/verbal communication skills.

Key Leadership Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance

• Learns fast, grasps the ‘essence’ and can change the course quickly where indicated

• Raises the bar and is never satisfied with the status quo

• Creates a learning environment, open to suggestions and experimentation for improvement

• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html