Senior Director, DMPK
Bicycle Therapeutics
Company DescriptionBicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.Culture is key and all Bicycle employees actively embrace and role model our company values:
Job DescriptionThe Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists, biologists, pharmacologists and toxicologists, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission. * Provide DMPK scientific leadership across all stages of the portfolio.
QualificationsEssential: * PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
Desirable: * Previous experience working on peptides-macrocycles would be an advantage.
Additional Information
All your information will be kept confidential according to EEO guidelines.Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
Great Abington, Cambridgeshire – Cambridge
Wed, 05 Jun 2024 22:42:48 GMT
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