Senior Principal Scientist – Enzymology

Job title:

Senior Principal Scientist – Enzymology

Firm

Most cancers Analysis UK

Job description

4,000 professionals, 0 days wasted, 1 unimaginable goal. Collectively, we’re beating most cancers.Senior Principal Scientist – EnzymologyWage: Beginning £67,200 – £76,000 relying on expertise and negotiableContract sort/hours: Everlasting, full time 35 hours per week (versatile working requests will likely be thought-about in the event that they meet enterprise wants)Location: Babraham Analysis Campus, Cambridge or CRUK Scotland Institute of Most cancers Analysis, GlasgowDeadline: 01 April 2024At Most cancers Analysis UK, we exist to beat most cancers.We’re professionals with goal, beating most cancers every single day. However we have to go a lot additional and far quicker. That’s why we we’re on the lookout for somebody proficient, somebody revolutionary and bold, somebody such as you.We’re on the lookout for a passionate Senior Principal Scientist to guide and drive our Mechanistic Enzymology technique, primarily based at our Babraham Analysis Campus amenities in Cambridge, or CRUK Scotland Institute amenities in Glasgow. That is an thrilling alternative and a good time to hitch us as we begin to implement our new 5-year plan.About Most cancers Analysis HorizonsAt Most cancers Analysis UK, our focus is on beating most cancers. Because the world’s greatest medical analysis charity, we’ve helped deliver eleven new most cancers medicine to market. Nonetheless, there’s nonetheless an pressing have to deliver more practical remedies to sufferers quicker.We have now not too long ago developed a brand new method to driving therapeutic innovation by way of the creation of Most cancers Analysis Horizons. We have now introduced collectively Most cancers Analysis UK’s established drug discovery groups below one organisation and management staff, combining our distinctive pipeline of world class biology, leading edge expertise platforms and medical experience to 1) deliver new remedies to sufferers quicker and a pair of) deal with the largest challenges in discovering most cancers medicine by in search of out extra radical concepts and embracing danger in our bid to realize success.We have now a significant concentrate on establishing and prosecuting biologically themed multi-project alliances with industrial companions, or by way of creation of latest firms. Based mostly on the Babraham Analysis Campus, Cambridge, the Milner Institute in Cambridge, Granta Park in Cambridge, the CRUK Scotland Institute in Glasgow, the Francis Crick Institute in London, and Newcastle College, Most cancers Analysis Horizons employs ~200 workers from each industrial and tutorial backgrounds.What is going to I be doing?Our new technique units out to deliver deeper mechanistic understanding on the molecular and mobile stage to all levels of tasks, from thought to pre-clinical candidate. Reporting on to the SVP Drug Discovery, you’ll set the imaginative and prescient and lead our mechanistic enzymology technique, serving to to determine the suitable medicine with the suitable mechanisms for the suitable sufferers, quicker. Additionally, you will play a management function within the wider Molecular Sciences division, contributing to the strategic course inside CRH.As our Senior Principal Scientist (SPS) Enzymology, you may be an inspirational scientist with an distinctive document of bringing your deep data of enzymology and drug-target kinetics to impression on tasks. You can be an skilled and passionate scientific chief, capable of signify the division throughout a broad vary of therapeutic tasks and cross-site initiatives, each internally and externally.You’ll contribute to, and lead, particular areas of scientific and technical innovation (together with in novel modalities aligned to our strategic course), incorporating exterior collaboration and partnership together with inside science builds. Additionally, you will lead drug discovery tasks. While this function is not going to handle any direct line-reports, a major ingredient will contain matrix management; additionally, you will play a pivotal function in coaching and growing colleagues, together with by way of your sensible contributions from the bench.We’re in search of an completed scientific chief who can articulate a imaginative and prescient for our mission and set course and encourage dedication for preclinical Drug Discovery.What is going to I be doing?Present deep experience in mechanistic enzymology and its function in drug discovery.Present scientific and strategic management for the Molecular Sciences division, and wider CRH, to drive innovation and portfolio success.Work on the intersection between mechanistic biology, medicinal chemistry, computational chemistry, structural biology & DMPK to outline and prosecute methods that ship mechanistic perception throughout a spread of difficult goal lessons, from preliminary goal characterisation by way of to medical dose prediction.Talk successfully, to affect a number of stakeholders and collaborate throughout tasks and websites, and externally.Promote scientific excellence, by way of exterior publication, shows, and membership of convention committees and Scientific Advisory Boards.Play a pivotal function in coaching and growing colleagues, together with by way of sensible contributions from the bench.What expertise and expertise are we on the lookout for?PhD in Enzymology, Pharmacology, or equal expertise.Vital expertise and deep experience in mechanistic enzymology in a drug discovery surroundings.Confirmed monitor document of revolutionary scientific supply by way of driving impactful mechanistic enzymology perception in drug discovery programmes, together with detailed characterisation of multi-substrate enzyme mechanisms and drug mechanism-of-action.Vital expertise in translating drug-target kinetics by way of to mechanistic PKPD modelling for therapeutic dose prediction.Confirmed monitor document of portfolio impression throughout a spread of difficult goal lessons, by way of mental and laboratory-based contributions, and undertaking management.Sturdy exterior repute in mechanistic enzymology and drug discovery, evidenced by way of broad private community, exterior presentation and publication in high-impact journals, and influential roles on related exterior committees.Vital expertise in inspiring and growing a various world-class group, while working in a extremely matrixed discovery undertaking surroundingsVital expertise of building and main exterior tutorial and industrial collaborations, and expertise change tasks.What is going to I achieve?Each one in every of our workers contributes to our progress and is supporting our work to beat most cancers. We expect that’s spectacular.In return, we be sure to are supported by a beneficiant advantages package deal, a variety of profession and private improvement alternatives and high-quality instruments, insurance policies, and processes to allow you to do your job effectively.Our advantages package deal features a substantial retirement plan, a beneficiant and versatile depart allowance, reductions on something from journey to expertise, health club membership, and way more.We evaluate pay yearly and goal to recognise particular person efficiency and achievements.We don’t overlook individuals have lives outdoors of labor too and so we actively encourage a versatile working tradition.Our work – from funding cutting-edge analysis to growing public coverage – will change the world. It’s thrilling to be a part of our staff.How do I apply?We function an anonymised shortlisting course of in our dedication to equality, range and inclusion. CVs are required for all functions; however we received’t be capable of view them till we invite you for an interview. As a substitute, we ask you to finish the work historical past part of the web utility type for us to have the ability to assess you shortly, pretty and objectively.There’s a spot for everybody at Most cancers Analysis UK. Our imaginative and prescient is to create a charity the place everybody seems like they belong, advantages from and participates in, the work we do. We’re dedicated to creating an inclusive tradition the place everybody may be themselves and attain their full potential.We actively encourage functions from individuals of all backgrounds and cultures, particularly these from ethnic minority backgrounds who’re at present under-represented, and imagine {that a} various workforce will assist us to beat most cancers sooner.Should you’re curious about making use of and enthusiastic about working with us however are not sure in case you have the suitable expertise and expertise we’d nonetheless love to listen to from you. We don’t count on everybody to satisfy all the standards listed.We wish to see each candidate acting at their finest all through the job utility course of, interview course of and while at work. We subsequently ask you to tell us of any considerations you could have or any changes you may have to allow this to occur by emailing us at .Sadly, we’re unable to recruit anybody under the age of 18, in order that we are able to shield younger individuals from well being & security and safeguarding dangers.

Anticipated wage

£67200 – 76000 per yr

Location

Cambridge – Babraham, Cambridgeshire

Job date

Thu, 14 Mar 2024 02:06:47 GMT

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