Senior Research Technician

University of Leeds

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Overview of the Role

Senior Research Technician in the Children’s Cancer Research Group, Leeds Institute of Medical Research at St James’s University Hospital, Leeds

Do you have a background in cancer cell biology and practical tissue culture skills? Do you want to further your experience in one of the UK’s leading research-intensive Universities? Do you want to develop your 2D and 3D tissue culture skills to evaluate new candidate treatment combinations that could be used to improve outcomes for young people with Ewing sarcoma? 

High levels of replication stress in Ewing sarcoma are moderated through the replication stress response and upregulation of the ATR-CHK1-WEE1 kinases, making these candidate therapeutic targets. In this study we will evaluate the efficacy of inhibitors to these kinases in 2D and 3D patient-derived Ewing sarcoma cultures, alone and in novel combinations with irinotecan or ionising radiation. We will also evaluate the effects of prioritised drugs in combination with standard-of-care chemotherapies. High-content imaging will be used to evaluate the effects of drugs on cell number and biomarkers of DNA damage and sensitivity. These studies may support the evaluation of WEE1 inhibition with irinotecan or irradiation for the treatment of patients with Ewing sarcoma.

To explore the post further or for any queries you may have, please contact:

Sue Burchill, Professor of childhood and adolescent cancer research

Email: [email protected]

Additional Information
Working at Leeds 

We are a campus based community and regular interaction with campus is an expectation of all roles in line with academic and service needs and the requirements of the role.  We are also open to discussing flexible working arrangements. To find out more about the benefits of working at the University and what it is like to live and work in the Leeds area visit our Working at Leeds information page. 

Our University  

As an international research-intensive university, we welcome students and staff from all walks of life. We foster an inclusive environment where all can flourish and prosper, and we are proud of our strong commitment to student education.  Within the Faculty of Medicine & Health we are dedicated to diversifying our community and we welcome the unique contributions that individuals can bring, and particularly encourage applications from, but not limited to Black, Asian, people who belong to a minority ethnic community; people who identify as LGBT+; and disabled people. Candidates will always be selected based on merit and ability. 

Information for disabled candidates

Information for disabled candidates, impairments or health conditions, including requesting alternative formats, can be found on our Accessibility information page or by getting in touch with us at [email protected]

Criminal Records

This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order (as amended) and as such, applicants are required to declare criminal records accordingly.  Appointees may also be required to complete a criminal record check from the Disclosure and Barring Service (DBS) and where relevant, equivalent overseas authorities.

Location:  Leeds – St James University Hospital
Faculty/Service:  Faculty of Medicine & Health
School/Institute:  Leeds Institute of Medical Research (LIMR)
Section:  Division of Molecular Medicine
Category:  Technical Support
Grade 6

£29,762 to £35,308
per annum pro-rata
Working Time:  Part-time 60% FTE
Post Type: 

Part Time
Contract Type:  Fixed Term (Available until 30 June 2024 due to external grant income)
Release Date:  Friday 02 June 2023
Closing Date:  Friday 16 June 2023
Reference:  MHLMR1121
Further details:

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