Senior Scientist, Antibody In Vitro Discovery – Biologics Engineering, Onc R&D

Job title:

Senior Scientist, Antibody In Vitro Discovery – Biologics Engineering, Onc R&D

Company

AstraZeneca

Job description

Position: Senior Scientist, Antibody In Vitro Discovery – Biologics Engineering, Onc R&DLocation: Cambridge – Discovery CentreCompetitive Salary & Excellent Company BenefitsIntroduction to role:Are you ready to push the boundaries of science? We are seeking a highly experienced and motivated Senior Scientist to support our therapeutic discovery pipeline, as well as technology development. You will be part of the In Vitro Discovery team, supporting campaigns to isolate and optimize therapeutic antibody candidates across AstraZeneca’s key disease areas. This is your chance to make a significant impact on the future of Oncology R&D!Accountabilities:As a Senior Scientist, you will be independent and proficient in designing and executing antibody discovery/optimisation campaigns using yeast display technology and related in vitro display platforms, demonstrating excellent analytical, communication, and documentation skills. You will work as part of multidisciplinary teams, supporting technology development programs, including design/generation of innovative antibody libraries and evolution of our next-generation discovery workflows. Your role will be pivotal in driving forward our ambitious research agenda.Essential Skills/Experience:

• A PhD level with relevant experience, or BSc/MSc degree with equivalent experience

• In depth knowledge and hands-on experience using a yeast display discovery methodology

• Experience in using FACS sorting of yeast library selections

• Proficiency with molecular biology and antibody engineering methods

• Ability to independently design, plan and execute antibody isolation/optimisation campaigns

• Ability to analyse/interpret data and communicate the results internally and externally

• Ability to troubleshoot and optimize protocols

• Ability to maintain accurate, high quality and up-to-date experimental records

• Effective communication skills and ability to work collaboratively in the multidisciplinary teams

• Willingness to learn and embrace innovative technologies

Desirable Skills/Experience:

• Experience using phage display, mammalian display or cell-free display technologies

• Good background in genetics of antibody diversity and biologics discovery process

• Experience in designing and generation of synthetic antibody/scaffold libraries

• Experience with next-generation sequencing applied to antibody discovery

• Experience in using computational methods applied to antibody design and optimisation

• Experience in high-throughput antibody screening and reformatting methods

• Experience with leading/co-leading and/or managing research projects

• Experience with managing or supervising people

Why AstraZeneca:At AstraZeneca, we follow the science. This core value guides our decision-making at every level. Our teams are encouraged to push the boundaries of science, continuously question and explore. We make bold moves at the cutting-edge, transforming molecules to change the practice of medicine. Since our renewed focus on building our Oncology function, we have had great successes with 7 new Oncology medicines since 2013. We set the tone for the rest of the industry, consistently publishing our findings in high impact journals, and leading with expertise and entrepreneurial spirit. In 2019 we invested $6.1bn in Research & Development. Join us as we continue to push forward.Call to Action:Are you ready to follow the science and pioneer new frontiers? Join our team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we are aiming to deliver 6 new molecular entities by 2025. Have the opportunity to build a rewarding and meaningful career as part of the team committed to improving the lives of millions with cancer. Apply today!Closing Date for Applications: COB 30 July 2024.Date Posted 15-Jul-2024Closing Date 30-Jul-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Expected salary

Location

Cambridge

Job date

Wed, 17 Jul 2024 03:15:40 GMT

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